Abstract

) Establishing a national network of investigators in the field of AIDS-related malignancies will enhance the development of improved therapies for these increasingly common complications of HIV disease. This proposal seeks to provide a structure by which laboratory and clinical investigators in Boston contribute an integrated effort to that cause. It formalizes the relationship between four clinical research programs and between clinical investigators and three laboratories with an interest in translational research. Included in the program are centers with widely diverse patient populations, a record of enrollment of 378 patients in related protocols and broad experience in the use of biologic therapies. Collaborating laboratories focusing on genetically or immunologically based therapeutics are expected to contribute to the development of novel treatment strategies for AIDS-related malignancies. Through the coordination of effort from these multiple sources, it is envisioned that the Boston consortium will augment the national program targeting AIDS- related malignancies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project--Cooperative Agreements (U01)
Project #
1U01CA071375-01
Application #
2115015
Study Section
Special Emphasis Panel (SRC (09))
Project Start
1995-09-30
Project End
1999-07-31
Budget Start
1995-09-30
Budget End
1996-07-31
Support Year
1
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199

  Publications

Dollard, Sheila C; Butler, Lisa M; Jones, Alison M Graves et al. (2010) Substantial regional differences in human herpesvirus 8 seroprevalence in sub-Saharan Africa: insights on the origin of the ""Kaposi's sarcoma belt"". Int J Cancer 127:2395-401
Lechowicz, Maryjo; Dittmer, Dirk P; Lee, Jeannette Y et al. (2009) Molecular and clinical assessment in the treatment of AIDS Kaposi sarcoma with valproic Acid. Clin Infect Dis 49:1946-9
Lin, Lan; Lee, Jeannette Y; Kaplan, Lawrence D et al. (2009) Effects of chemotherapy in AIDS-associated non-Hodgkin's lymphoma on Kaposi's sarcoma herpesvirus DNA in blood. J Clin Oncol 27:2496-502
Ratner, Lee; Harrington, William; Feng, Xuan et al. (2009) Human T cell leukemia virus reactivation with progression of adult T-cell leukemia-lymphoma. PLoS One 4:e4420
Spitzer, Thomas R; Ambinder, Richard F; Lee, Jeannette Y et al. (2008) Dose-reduced busulfan, cyclophosphamide, and autologous stem cell transplantation for human immunodeficiency virus-associated lymphoma: AIDS Malignancy Consortium study 020. Biol Blood Marrow Transplant 14:59-66
Stier, Elizabeth A; Goldstone, Stephen E; Berry, J Michael et al. (2008) Infrared coagulator treatment of high-grade anal dysplasia in HIV-infected individuals: an AIDS malignancy consortium pilot study. J Acquir Immune Defic Syndr 47:56-61
Noy, Ariela; von Roenn, Jamie; Politsmakher, Alex et al. (2007) Fatal hepatorenal failure and thrombocytopenia with SU5416, a vascular endothelial growth factor Flk-1 receptor inhibitor, in AIDS-Kaposi's sarcoma. AIDS 21:113-5
Krown, Susan E; Lee, Jeannette Y; Lin, Lan et al. (2006) Interferon-alpha2b with protease inhibitor-based antiretroviral therapy in patients with AIDS-associated Kaposi sarcoma: an AIDS malignancy consortium phase I trial. J Acquir Immune Defic Syndr 41:149-53
Dezube, Bruce J; Krown, Susan E; Lee, Jeannette Y et al. (2006) Randomized phase II trial of matrix metalloproteinase inhibitor COL-3 in AIDS-related Kaposi's sarcoma: an AIDS Malignancy Consortium Study. J Clin Oncol 24:1389-94
Kaplan, Lawrence D; Lee, Jeannette Y; Ambinder, Richard F et al. (2005) Rituximab does not improve clinical outcome in a randomized phase 3 trial of CHOP with or without rituximab in patients with HIV-associated non-Hodgkin lymphoma: AIDS-Malignancies Consortium Trial 010. Blood 106:1538-43

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