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Preclinical studies of a MADCAM-Fc fusion protein in multiple sclerosisMultiple Sclerosis (MS), an autoimmune disease of the central nervous system (CNS), is the most common non-traumatic cause of neurological disability among young adults in the United States. Exacerbations of...
The development of a recombinant vaccine against human onchocerciasisHuman onchocerciasis is a serious neglected tropical disease caused by Onchocerca volvulus (Ov) and an important cause of blindness and chronic disability in the developing world. Through mass drug administration...
Molecular Pathogenesis of Flavivirus EncephalitisThis research proposal concerns the molecular pathogenesis of disease caused by flaviviruses. These viruses include many agents of arthropod- transmitted encephalitis and hemorrhagic fever which cause serious human illness on...
Internet Connection9405416 Krug Bethany College requests support from NSF for connection of their campus networks to the midlevel network in West Virginia, WVNET, and from their to SURAnet. SURAnet is the...
Combatting natural resistance and persistence in non-TB mycobacterial diseaseWhereas tuberculosis (TB) lung disease, caused by Mycobacterium tuberculosis is decreasing, lung disease due to a group of close relatives of the tubercle bacillus called `Non-Tuberculous Mycobacteria' or NTM, is...
Production of a Gonococcal Vaccine for Countering Antimicrobial ResistanceProgram Director/Principal Investigator: Schryvers, Anthony B. ABSTRACT Neisseria gonorrhoeae, the bacterial pathogen that causes gonorrhea, is now considered an ?Urgent Threat? due to the recent emergence of strains with multi-drug...
Circadian Rhythms and Innate Immune Response in AgingCircadian rhythms play crucial roles in a wide range of physiologic and behavioral processes. In mammals, variations in light intensity and other environmental cues are integrated by a master pacemaker...
AgTRIO, a protein in mosquito saliva, influences Plasmodium sporozoite infectionMalaria is a global infectious disease that causes profound morbidity and mortality. RTS,S - currently the most advanced malaria vaccine ? is based upon the Plasmodium circumsporozoite protein (CSP) in...
The postdoctoral training period is nearly essential for all research scientists who aspire to lead a research laboratory in a university or non-profit research center. To characterize the transition of scientists from postdoc to established PI, we previously conducted an analysis of how many postdocs with a NIH-sponsored F32 fellowship went on to become PIs of a R-esearch grant. In 2006, NIH int...
Previously, we calculated the fraction of the R01 grant pool that each institution has obtained in 2013, and how this fraction has changed over time. We now wanted to perform a complementary analysis, determining institutional variability in the length of time that individual PIs are able to maintain NIH grant funding. This analysis would be of interest to university administrators who want to rec...
In our database, for any grant we report "Related Projects" that are renewals of ongoing projects from individual investigators. We wanted to improve this by identifying "Related Projects" more generally in which we group different grants based on the text in the abstract. We analyzed the similarities of 2013 NIH grant abstracts with lengths of at least 100 words (disregarding the public health r...
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