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The entirety of funding information.
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Repair of Genome Destabilizing DNA StructuresTranslocations are known to be involved in the etiology of many cancers, and DNA double-strand breaks (DSBs) are an essential first step in the formation of many oncogenic translocations. However,...
Regulation of Chromatin Structure Dynamics in Hematopoietic and Leukemic Stem CelOur long-term research goals are to understand the mechanisms that regulate stem cell fate decisions. This proposal focuses on epigenetic regulation of cell identity. Open chromatin has been proposed as...
Rapid DPP test for tuberculosisTuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis with an estimated two billion people currently infected worldwide and over nine million new cases detected annually worldwide. This is...
Structure of Viral RNA and Its Role in AssemblyA variety of physical and chemical techniques, chief among them being X-ray crystallography, will be applied to a series of icosahedral viruses with the ultimate objectives of (1) deducing the...
Technology-based intervention for alcohol-related sexual risk behaviors in young women with sexual victimization historiesThe long-term objective of this Pathway to Independence Award is two-fold: (1) support candidate Dr. Blayney in building an independent research program and (2) facilitate her transition from postdoctoral fellow...
Melanocortin 3 receptor in neural circuits linking reproductive state and metabolismNeural circuits modulating metabolic state and reproduction must communicate with each other to maintain homeostasis. Despite an increasing prevalence of both metabolic and reproductive disorders, our understanding of neural circuitry...
Developmental Pesticide Exposure and Epigenetic Aging in the BrainThe majority (~90%) of Parkinson's disease (PD) cases are not caused by an inherited monogenic mutation, but are rather likely due to a complex interaction between genes and environmental factors....
IL-21 as a Therapeutic to Reduce Immune Activation and Normalize Microbial Dysbiosis in SIV-Infected ART-Suppressed Infant MacaquesGlobally, 1.8 million children are living with HIV-1 and over half of the ~180,000 new infections annually occur postnatally through breast milk transmission. While antiretroviral therapy (ART) has improved disease...
The postdoctoral training period is nearly essential for all research scientists who aspire to lead a research laboratory in a university or non-profit research center. To characterize the transition of scientists from postdoc to established PI, we previously conducted an analysis of how many postdocs with a NIH-sponsored F32 fellowship went on to become PIs of a R-esearch grant. In 2006, NIH int...
Previously, we calculated the fraction of the R01 grant pool that each institution has obtained in 2013, and how this fraction has changed over time. We now wanted to perform a complementary analysis, determining institutional variability in the length of time that individual PIs are able to maintain NIH grant funding. This analysis would be of interest to university administrators who want to rec...
In our database, for any grant we report "Related Projects" that are renewals of ongoing projects from individual investigators. We wanted to improve this by identifying "Related Projects" more generally in which we group different grants based on the text in the abstract. We analyzed the similarities of 2013 NIH grant abstracts with lengths of at least 100 words (disregarding the public health r...
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