This competing renewal application for the Columbia University International Training Program in Epidemiology of AIDS builds on the successes of the last seven years. The past 18 long-term and 20 short-term Fellows of the Program have been scientifically productive, have made major new scientific contributions, have been instrumental in South Africa's success in securing competitive international grants and have taken up several key leadership positions. Based on the past successes, the proposed program will be based on the concept of a """"""""continuum of training"""""""" where the mentorship, training and placements in the USA are seamlessly linked to the mentorship, practical training and research experiences in South Africa. The proposed program is extended in this proposal, into a multidisciplinary program including Public Health and Epidemiology, Social and Behavioral Science and Basic Science, for both AIDS and tuberculosis. An ethics training initiative is included. Besides the several senior Faculty from both the USA and South Africa, the Program includes a 6 member Executive Committee and a 16 member Steering Committee with balanced disciplinary and country representation. The Program will have strong links with other training programs funded by Fogarty or other agencies, as well as with NIH funded research both in the USA and South Africa. Fellows will be carefully selected for one of the eight training categories, the emphasis in the Program will be on long term training in the USA with periods spent in South Africa doing research, preferably research linked to NIH funded projects, such as HIV prevention trials. Within the southern African region, the multiplier effect of the USA based training is achieved through past Fellows teaching in the Southern African Summer School Programs. The Program will be monitored by the success of past Fellows, the positions they obtain in South Africa, the role they play in AIDS and tuberculosis control and their level of success in obtaining grants and publishing important relevant research findings.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Training Grants (D43)
Project #
5D43TW000231-10
Application #
6781873
Study Section
Special Emphasis Panel (ZAI1-GLM-F (S1))
Program Officer
Mcdermott, Jeanne
Project Start
1993-06-01
Project End
2005-05-31
Budget Start
2004-06-01
Budget End
2005-05-31
Support Year
10
Fiscal Year
2004
Total Cost
$662,340
Indirect Cost
Name
Columbia University (N.Y.)
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
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Naidoo, Anushka; Ramsuran, Veron; Chirehwa, Maxwell et al. (2018) Effect of genetic variation in UGT1A and ABCB1 on moxifloxacin pharmacokinetics in South African patients with tuberculosis. Pharmacogenomics 19:17-29
Dawood, Halima; Hassan-Moosa, Razia; Zuma, Nonhlanhla-Yende et al. (2018) Mortality and treatment response amongst HIV-infected patients 50 years and older accessing antiretroviral services in South Africa. BMC Infect Dis 18:168
Suliman, Sara; Thompson, Ethan; Sutherland, Jayne et al. (2018) Four-gene Pan-African Blood Signature Predicts Progression to Tuberculosis. Am J Respir Crit Care Med :
Naidoo, Kogieleum; Yende-Zuma, Nonhlanhla; Augustine, Stanton (2018) A retrospective cohort study of body mass index and survival in HIV infected patients with and without TB co-infection. Infect Dis Poverty 7:35
Moosa, Yumna; Tanko, Ramla F; Ramsuran, Veron et al. (2018) Case report: mechanisms of HIV elite control in two African women. BMC Infect Dis 18:54
Anthony, Colin; York, Talita; Bekker, Valerie et al. (2017) Cooperation between Strain-Specific and Broadly Neutralizing Responses Limited Viral Escape and Prolonged the Exposure of the Broadly Neutralizing Epitope. J Virol 91:
Thobakgale, Christina; Naidoo, Kewreshini; McKinnon, Lyle R et al. (2017) Interleukin 1-Beta (IL-1?) Production by Innate Cells Following TLR Stimulation Correlates With TB Recurrence in ART-Treated HIV-Infected Patients. J Acquir Immune Defic Syndr 74:213-220
Naidoo, Anushka; Chirehwa, Maxwell; McIlleron, Helen et al. (2017) Effect of rifampicin and efavirenz on moxifloxacin concentrations when co-administered in patients with drug-susceptible TB. J Antimicrob Chemother 72:1441-1449
Lutge, Elizabeth; Slack, Catherine; Wassenaar, Douglas (2017) Defining and Negotiating the Social Value of Research in Public Health Facilities: Perceptions of Stakeholders in a Research-Active Province of South Africa. Bioethics 31:128-135

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