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Humanizing Regulators of the Complement Cascade to Improve Research RelevanceActivation of the complement cascade occurs in development, aging and a wide variety of human disease including neurodegenerative diseases, autoimmune diseases and in response to infections. Much of our understanding...
Core Violence and Injury Prevention Program (Core VIPP) Quantitative Magnetic Resonance Imaging of PerfusionThe objective of this work is to develop techniques for quantitative non-invasive imaging of tissue perfusion using magnetic resonance imaging. The motivation for this project is too classes of applications:...
Genomic Organization of Zein Gene SubfamiliesThe developing endosperm tissue of the maize kernel represents an excellent system to study the molecular biology of the coordination and timing of the activity of families of genes. The...
Novel Functions of Lung Macrophages and Fibroblasts in Pulmonary Inflammation and FibrosisThe PI of this OIA application is a physician-scientist with an outstanding record of contributions to science, education and mentoring, clinical practice, and professional leadership and service. During his 30-year...
Renewing the heart: cardiomyocyte cell cycle regulationHeart failure remains a leading cause of morbidity and mortality worldwide. A major issue in the setting of heart failure is loss of cardiomyocytes, and the inability of adult mammalian...
Diagnosis, Prevention, And Treatment Of Cardiovascular Diseases With Genome EditingFor the past 6 years, my independent laboratory has leveraged new approaches in human genomics and pioneered new types of post-genomic functional studies?empowered by genome-editing technologies?to elucidate novel mechanisms that...
An mHealth Strategy to Improve Medication Adherence in Adolescents with Sickle Cell Disease) Research: Sickle cell disease (SCD) is the most common genetic disorder in the US, affecting about 100,000 Americans, and about 1 in 400 African American live births, incurring annual...
The postdoctoral training period is nearly essential for all research scientists who aspire to lead a research laboratory in a university or non-profit research center. To characterize the transition of scientists from postdoc to established PI, we previously conducted an analysis of how many postdocs with a NIH-sponsored F32 fellowship went on to become PIs of a R-esearch grant. In 2006, NIH int...
Previously, we calculated the fraction of the R01 grant pool that each institution has obtained in 2013, and how this fraction has changed over time. We now wanted to perform a complementary analysis, determining institutional variability in the length of time that individual PIs are able to maintain NIH grant funding. This analysis would be of interest to university administrators who want to rec...
In our database, for any grant we report "Related Projects" that are renewals of ongoing projects from individual investigators. We wanted to improve this by identifying "Related Projects" more generally in which we group different grants based on the text in the abstract. We analyzed the similarities of 2013 NIH grant abstracts with lengths of at least 100 words (disregarding the public health r...
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