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Generation and characterization of human B1 B cells induced by Lin28b reprogramming of adult hematopoietic progenitorsCD5+ B1 B cells in mice constitute a pool of natural autoreactive B cells that carry out many important functions, including clearance of apoptotic cells, making rapid responses to pathogens,...
Prediction of the Structure of Therapeutic Antibodies with their AntigensAntibodies play a critical role in the immune system for recognition of foreign intruders. Because of their excellent affinity and specificity, they hav also been exploited as therapeutic molecules and...
Inhalational Injury Sustained by Firefighters on 9/11/01
Composition, Assembly and Replication of RNA VirusesOur laboratory will study the mechanism(s) involved in the regulation of the functions of the virus-specific, virion-associated RNA polymerases of the two minus-stranded RNA animal viruses, vesicular stomatitis virus (VSV)...
Epigenetic and cellular markers of stress sensitization by early life stress in miceSection This project will be continued at Princeton University in the Princeton Neuroscience Institute. Early life stress (ELS) is one of the strongest lifetime risk factors for developing depression and...
Biophysical basis of functional MRI of white matterThe proposed research aims to measure blood oxygenation level dependent (BOLD) signals in white matter (WM) using functional magnetic resonance imaging (fMRI), validate their relationships to cortical neural activity, and...
Cross talk between epithelial, inflammatory and mesenchymal cells in the development of portal fibrosisThere is considerable interest in understanding the mechanistic relationships between biliary damage and portal fibrosis, the main mechanism of progression in chronic cholangiopathies. Congenital Hepatic Fibrosis (CHF) and Caroli disease...
Neighborhoods, Networks, and the HIV Care Continuum among HIV-infected MSM in NYCMarked disparities by race/ethnicity exist in HIV infection rates and engagement and retention in care among men who have sex with men (MSM) along the HIV care continuum. Compared with...
The postdoctoral training period is nearly essential for all research scientists who aspire to lead a research laboratory in a university or non-profit research center. To characterize the transition of scientists from postdoc to established PI, we previously conducted an analysis of how many postdocs with a NIH-sponsored F32 fellowship went on to become PIs of a R-esearch grant. In 2006, NIH int...
Previously, we calculated the fraction of the R01 grant pool that each institution has obtained in 2013, and how this fraction has changed over time. We now wanted to perform a complementary analysis, determining institutional variability in the length of time that individual PIs are able to maintain NIH grant funding. This analysis would be of interest to university administrators who want to rec...
In our database, for any grant we report "Related Projects" that are renewals of ongoing projects from individual investigators. We wanted to improve this by identifying "Related Projects" more generally in which we group different grants based on the text in the abstract. We analyzed the similarities of 2013 NIH grant abstracts with lengths of at least 100 words (disregarding the public health r...
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