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Endogenous Agmatine in Glutamatergic Pain ProcessingThis application is for a Mentored Research Scientist Development Award (K01). Recently, agmatine (decarboxylated arginine) has been isolated from mammalian brain and spinal cord. Agmatine both antagonizes the NMDA receptor...
The Nichd Study of Early Child Caredescription) The goal of Phase II of the NICHD Study of Early Child Care is to extend a collaborative (10-site) prospective longitudinal study of a cohort of 1247 children and...
A Study of Moduli of Riemann Surfaces via the Weil-Petersson Geometry of Teichmuller Spaces9701303 Tian This project concerns various Riemannian geometric properties of the Teichmuller space, which in turn gives a new way to parametrize the moduli of compact Riemann surfaces. More specifically,...
A Renormalization Group Approach to Interconnection OptimizationChristie Recent advances in statistical physics based on the concept of the renormalization group are applied to the problem of computer interconnection optimization. This enables a thermodynamic model of system...
Autophagy Against Tuberculosis and HIVThe outcome of Mycobacterium tuberculosis (Mtb) infection depends on host?s immune, metabolic and tissue- protective responses. Autophagy is a process that contributes to all three aspects of protection against tuberculosis...
The Role of the De-condensed Structure of Nascent Chromatin During T Cell DifferentiationDuring cell differentiation, transcriptional programs are changed, and then must be maintained in turn. Chromatin-based epigenetic mechanisms are at the core of maintenance and switching of transcriptional programs. The fundamental...
Protein microarray antibody responses to P. falciparum in a human challenge modelThis K23 application is submitted by Andrea A. Berry, M.D., an Assistant Professor of Pediatrics at the University of Maryland School of Medicine. Dr. Berry's long term goal is to...
Administrative CoreTheproposedAdministrativeCore(CoreA)willinteractcloselywilleachoftheproposed4projectsandthe twootherproposedcores:theScientificCoreandtheDataManagementandAnalysisCore.Wehave developedadetailedplantostrivetooptimizethesynergyandinteractionsamongthepro...
The postdoctoral training period is nearly essential for all research scientists who aspire to lead a research laboratory in a university or non-profit research center. To characterize the transition of scientists from postdoc to established PI, we previously conducted an analysis of how many postdocs with a NIH-sponsored F32 fellowship went on to become PIs of a R-esearch grant. In 2006, NIH int...
Previously, we calculated the fraction of the R01 grant pool that each institution has obtained in 2013, and how this fraction has changed over time. We now wanted to perform a complementary analysis, determining institutional variability in the length of time that individual PIs are able to maintain NIH grant funding. This analysis would be of interest to university administrators who want to rec...
In our database, for any grant we report "Related Projects" that are renewals of ongoing projects from individual investigators. We wanted to improve this by identifying "Related Projects" more generally in which we group different grants based on the text in the abstract. We analyzed the similarities of 2013 NIH grant abstracts with lengths of at least 100 words (disregarding the public health r...
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