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anonymous on The Rise and Fall of the Dominant FewThe New York schools, like Mount Sinai, are some of the most cutthroat places to work. They have no problem with reducing your salary down to 10% if your grants...
BD on A study to improve the fit of HIV prevention methodsFinally the kind of research that I want my government to pay for! And it is already in the stage of clinical trials. :)
random observer on Seattle-Lausanne-Kampala CTUThis grant has reviewer comments in Abstract! How could it be funded at <10% success rate if 'Reviewers express a strong concern ...
PI on The Rich and the Rest Looking at the R01 distribution, the trend for 2014 & 2015 does not look that hot.
Susan Carr on CGRP's effect on hearing and balance in a mouse model of migraineI am 64 and have chronic migraine. In 2018, I tried Emgality. It triggered severe neck pain and vertigo. I discontinued Emgality after two rounds. I continued having the stiff...
Hagar2 on Hygromycin A: Activity, Biosynthesis, Export, Resistance and RegulationHow did Flightpath end up with the license for this drug.
Cameron on The Norepinephrine Transporter: A Novel Target for Imaging Brown Adipose TissueWhere is the evidence that cold exposure results in NET up-regulation?
James on Participatory Action Research to Inform a Social-Ecological Model of Gun-Related Attitudes, Behaviors, and Practices1996 Dickey Amendment. How interesting, "including factors that might influence engagement in those strategies; and (e) ideas for novel prevention strategies." Language that...well let's just see wh...
Studies of TRAF3 in age-related low-level chronic inflammation and osteoporosisOsteoporosis is a leading disease of aging characterized by decreased bone mass and increased fracture risk as a consequence of increased bone resorption by osteoclasts (OCs) and decreased bone formation...
The Role of Sortilin in the Regulation of Apolipoprotein B Secretion from the liver and heartCardiometabolic diseases including coronary artery disease (CAD) and type 2 diabetes (T2D) are major causes of death and morbidity in all societies. These and other metabolic diseases have common etiological...
Assembly of Novel Gene Editing Particles to Understand Genome Surgery in Patient-Derived CellsThere is a fundamental gap in understanding how several components of engineered gene-editing nucleases achieve gene modification in human cells. Continued existence of this gap represents an important problem because,...
Regulation of Bacteriophage P2 Late Gene ExpressionTranscription of the late genes of bacteriophage P2 depends on the P2 DNA replication genes, the P2 ogr gene product, and the host RNA polymerase. Satellite phage P4 can activate...
The effect of Strongyloides stercoralis on HTLV-1 disease progressionHTLV-1 is a retrovirus that infects 10-20 million people worldwide with a seroprevalence of 2-3% in Peru. HTLV-1 infects CD4+ T lymphocytes, causing cells to be immortalized. Clinical manifestations include...
Organ-specific autoimmunity resulting from two genetic defects in toleranceA diversity of tolerance mechanisms work together to prevent autoimmune disease in most individuals by limiting the activity of self-reactive lymphocytes. How genetically determined defects in particular tolerance pathways may...
TOLLIP Deficiency, Immune Dysregulation, and Tuberculosis SusceptibilityOver one million people died from tuberculosis (TB) in 2016. Improved understanding of the host factors that influence TB infection and TB disease severity is needed to improve TB treatments...
Elucidating repair processes central to fluoroquinolone persistence in growth-inhibited populationsMany antibiotics rapidly kill growing populations of bacteria but struggle to kill non-growing populations. Even for drugs that can kill the majority of growth-inhibited bacteria, such as fluoroquinolones (FQs), the...
The postdoctoral training period is nearly essential for all research scientists who aspire to lead a research laboratory in a university or non-profit research center. To characterize the transition of scientists from postdoc to established PI, we previously conducted an analysis of how many postdocs with a NIH-sponsored F32 fellowship went on to become PIs of a R-esearch grant. In 2006, NIH int...
Previously, we calculated the fraction of the R01 grant pool that each institution has obtained in 2013, and how this fraction has changed over time. We now wanted to perform a complementary analysis, determining institutional variability in the length of time that individual PIs are able to maintain NIH grant funding. This analysis would be of interest to university administrators who want to rec...
In our database, for any grant we report "Related Projects" that are renewals of ongoing projects from individual investigators. We wanted to improve this by identifying "Related Projects" more generally in which we group different grants based on the text in the abstract. We analyzed the similarities of 2013 NIH grant abstracts with lengths of at least 100 words (disregarding the public health r...
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