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Dissection of Mycobacterium tuberculosis metabolic and regulatory pathways to perThe goal of the program is to identify the key metabolic pathways/reactions and regulatory transcription factors that are associated with M. tuberculosis growth arrest (a physiological state related to persistent...
Cyclophosphamide in the Treatment of Motor Neuron DiseaseIt has recently been discovered that some patients with motor neuron disease have an attack upon the motor nerves that is launched by the body immune system. Treatment with cyclophosphamide...
Dose Intense Mopp for Patients with Poor Prognosis Hodgkin's DiseaseThis protocol was designed to treat the subset of Hodgkin's disease patients who are at highest risk for treatment failure. From the previous study of advanced Hodgkin's disease, we have...
Mathematical Sciences: Model Theory of Fields and of Their Galois Groups Safety and modulation of ABCC9 pathways by nicorandil for the treatment of hippocampal sclerosis of aging (SMArTHS)The proposed project is a pilot clinical trial investigating a potential treatment for hippocampal sclerosis of aging (HS-Aging). A major subtype of ?Alzheimer's disease and related dementia? (ADRD), HS-Aging affects...
Mechanisms of erythropoietin induced hypertensionHypertension is a common but a frequently overlooked and underreported adverse effect of erythropoietin (EPO) therapy. Although EPO was approved in 1989 for treatment of anemia in patients with chronic...
Structural and functional neural alterations in suicidality among Veterans with PTSDResearch: Veterans of the U.S. military die by suicide at a rate of two to six times that of their civilian counterparts. Suicidal ideation (SI) and suicide attempts (SA), cardinal...
Extracellular matrix-adipocyte metabolic crosstalk and diabetesObesity and associated metabolic disease, including type II diabetes, is a public health crisis, the risks of which are elevated in military Veterans. Adipose tissue metabolism is dysregulated in obesity...
The postdoctoral training period is nearly essential for all research scientists who aspire to lead a research laboratory in a university or non-profit research center. To characterize the transition of scientists from postdoc to established PI, we previously conducted an analysis of how many postdocs with a NIH-sponsored F32 fellowship went on to become PIs of a R-esearch grant. In 2006, NIH int...
Previously, we calculated the fraction of the R01 grant pool that each institution has obtained in 2013, and how this fraction has changed over time. We now wanted to perform a complementary analysis, determining institutional variability in the length of time that individual PIs are able to maintain NIH grant funding. This analysis would be of interest to university administrators who want to rec...
In our database, for any grant we report "Related Projects" that are renewals of ongoing projects from individual investigators. We wanted to improve this by identifying "Related Projects" more generally in which we group different grants based on the text in the abstract. We analyzed the similarities of 2013 NIH grant abstracts with lengths of at least 100 words (disregarding the public health r...
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