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anonymous on The Rise and Fall of the Dominant FewThe New York schools, like Mount Sinai, are some of the most cutthroat places to work. They have no problem with reducing your salary down to 10% if your grants...
BD on A study to improve the fit of HIV prevention methodsFinally the kind of research that I want my government to pay for! And it is already in the stage of clinical trials. :)
random observer on Seattle-Lausanne-Kampala CTUThis grant has reviewer comments in Abstract! How could it be funded at <10% success rate if 'Reviewers express a strong concern ...
PI on The Rich and the Rest Looking at the R01 distribution, the trend for 2014 & 2015 does not look that hot.
Anonymike on Impact of Methamphetamine Induced IL-6 Production on Wound Healing and InflammationI'm a cannabis user. I suffer from complications from scleroderma and raynaud's. I occasionally use meth. On average once a month. I make it a point not to know where...
andyrwebman on Removable transcatheter aortic valveThis has actually been done before - and it's a good solution. ValveXChange Inc created a two part valve with a removable modular part. There were two variants: one where...
Aniket Agarwal on Microfluidic CAR-T Cell Processing Devicewere any design specifications/considerations developed/found?
Happy Kid on Brain and behavior in individuals with intersex conditionsI wonder how the recent Wuhan virus affect intersex people. They say usually older, heavier males have higher risks than females, so does it mean the risk for intersex people...
Computer assisted coronary artery stent interventionsComputer assisted coronary artery stent interventions Summary When treating highly calcified coronary artery lesions with stents, interventional cardiologists, with limited in- formation, make stressful treatment decisions, which can lead to...
Using Values to Enhance Inmates' Response to Substance Use and HIV Risk FeedbackCapitalizing on cutting edge research on values affirmation and personalized risk feedback from psychology and criminology, we aim to develop, implement, and pilot test a one session computer-assisted intervention tailored...
Enamel Fluorosis: Mechanisms of ActionEnamel fluorosis is a defect in enamel development that occurs after exposure to excess fluoride. Fluorotic enamel is more porous, and contains more proteins than sound enamel. The mechanisms by...
Role and Mechanism of BMP4 and BMP2 Action and Signaling in BoneMutations in the human BMP4 and BMP2 genes have been associated with osteoporosis and these BMPs signal through a variety of BMP receptors. The role for BMP2 and BMP4 in...
Topographic, cell type and molecular pathway characterization ofAlzheimer's disease using single cell transcriptomics and epigenomics(PROJECT 2) Alzheimer's disease (AD) is a highly penetrant neurodegenerative disease projected to affect 13.8 million cases in the US by 2050 at a cost of $1.1 trillion if no...
Spatial analysis of regional, cell type and molecular hallmarks of Alzheimer's disease(PROJECT 3) The molecular mechanisms underlying cellular vulnerability in Alzheimer?s disease are unclear. The objective of this project is to clarify the molecular mechanisms responsible for select cell vulnerability and...
Identification of Regulatory Loci of Stx2a Cytotoxin Production in Shiga toxin producing Escherichia coli (STEC)Globally disseminated Shiga toxin (Stx)-producing Escherichia coli (STEC) are notorious for producing a phage-borne cytotoxin, that is direct mediator of lethal food borne disease. Human morbidity and mortality remain unacceptably...
A phenomics-first resource for interpretation of variantsA Phenomics-First Resource (PFR) for interpretation of variants Genomics is key to precision medicine; however, despite the ease of sequencing, clinical interpretation is still thwarted because relevant data (disease, phenotype,...
The postdoctoral training period is nearly essential for all research scientists who aspire to lead a research laboratory in a university or non-profit research center. To characterize the transition of scientists from postdoc to established PI, we previously conducted an analysis of how many postdocs with a NIH-sponsored F32 fellowship went on to become PIs of a R-esearch grant. In 2006, NIH int...
Previously, we calculated the fraction of the R01 grant pool that each institution has obtained in 2013, and how this fraction has changed over time. We now wanted to perform a complementary analysis, determining institutional variability in the length of time that individual PIs are able to maintain NIH grant funding. This analysis would be of interest to university administrators who want to rec...
In our database, for any grant we report "Related Projects" that are renewals of ongoing projects from individual investigators. We wanted to improve this by identifying "Related Projects" more generally in which we group different grants based on the text in the abstract. We analyzed the similarities of 2013 NIH grant abstracts with lengths of at least 100 words (disregarding the public health r...
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