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Making cancer precision medicine real: bottlenecks and opportunitiesThe concept of cancer precision medicine is simple: patient treatments are guided by the molecular features of their tumor. In practice, however, the situation is more complex. Only a minority...
Exploring preclinical amyloid pathology with optical microscopyThis project will investigate early pathophysiological hallmarks of Alzheimer's disease (AD) using newly- developed microscopy tools. Alzheimer's disease (AD) is a devastating, irreversible neurodegenerative disorder that currently has no effective...
Modeling the effects of fibrosis on skeletal muscle homeostasis. In our aging society, degenerative complications of chronic disease are on the rise and account for a significant percentage of deaths. Among these, fibrosis is the most common, and...
Investigating addictive/compulsive feeding behaviorTo determine the impact of chronic activation of AGRP or POMC on addictive or compulsive feeding behavior. Hypothesis: Chronic activation of AGRPARC will result in compulsive feeding behavior, and chronic...
Role of IL-6 and IL-1b in immune dysfunction during aging, HIV, and HCV infectionChronic systemic inflammation is associated with immune dysfunction and morbidities in the elderly, treated HIV infection, and HCV infection. We propose that circulating inflammatory proteins drive immune exhaustion and senescence...
6-week trial of oxytocin for co-occurring cocaine and opioid use disordersHigh rates of substance use disorders in Veterans compared to the general population are heavily influenced by psychosocial factors ? such as difficulty reintegrating into civilian life due to avoidance...
Lysophosphatidic acid and cardiovascular disease riskVeterans have a higher incidence of cardiovascular disease than the general population. Cardiovascular disease risk is caused by environmental and heritable factors. The broad goal of our research is to...
Nonsuicidal Self Injury in VeteransThere is a critical need to identify risk factors associated with increased suicidality in Veterans. Nonsuicidal self-injury (NSSI) refers to the deliberate destruction of body tissue without conscious intent to...
The postdoctoral training period is nearly essential for all research scientists who aspire to lead a research laboratory in a university or non-profit research center. To characterize the transition of scientists from postdoc to established PI, we previously conducted an analysis of how many postdocs with a NIH-sponsored F32 fellowship went on to become PIs of a R-esearch grant. In 2006, NIH int...
Previously, we calculated the fraction of the R01 grant pool that each institution has obtained in 2013, and how this fraction has changed over time. We now wanted to perform a complementary analysis, determining institutional variability in the length of time that individual PIs are able to maintain NIH grant funding. This analysis would be of interest to university administrators who want to rec...
In our database, for any grant we report "Related Projects" that are renewals of ongoing projects from individual investigators. We wanted to improve this by identifying "Related Projects" more generally in which we group different grants based on the text in the abstract. We analyzed the similarities of 2013 NIH grant abstracts with lengths of at least 100 words (disregarding the public health r...
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