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Accumulated white matter fiber strain from repetitive head impacts in contact sportsSports-related concussion is a growing health and socio-economical problem and yet, its biomechanical mechanisms are still poorly understood. Accurate quantification of how mechanical energy from an external impact is transferred...
In Vivo Analysis of the Mechanisms of Neural Crest MigrationOne of the most devastating birth defects affect the neural crest, a highly migratory stem cell-like population that contribute to craniofacial and cardiovascular development, and peripheral and enteric nervous system...
Method Development for the Analysis of PBDEs in Human Placenta TissueA large number of human placenta samples have been collected from a multi-racial cohort children health study at the Boston Medical Center and another study entitled """"""""Family and Children of...
Organization of the Spinal CordThe objective of this proposal is to determine the neural circuits and cellular mechanisms which produce a state of generalized enhanced excitability in the lamprey brain. This active state is...
Computational and functional strategies to decipher lncRNAs in human atherosclerosisThis proposal addresses knowledge gaps in cell-specific function and disease causation of long non-coding RNAs (lncRNAs) in human atherosclerosis. Despite prominent examples of functional lncRNAs in cardiovascular diseases (CVD), their...
COHERE ? COntextualized care in cHcs? Electronic health RecordsFactors such as food, transportation, and housing instability, social isolation, and neighborhood conditions profoundly impact health outcomes. Shaped by a long history of racial, social, and economic inequity in the...
PET Detection of CCR2 in Human AtherosclerosisA central modern tenet of atherosclerosis is that inflammation is a key driver of the process, and likely provides at least a partial explanation for the excess CVD risk observed...
Pharmacological Actions of Stress and AntidepressantsThe objective of this R01 grant renewal is to characterize two novel transcriptional regulators, not previously implicated in stress or depression?and nearly unstudied in any neural phenomena?in mediating resilience to...
The postdoctoral training period is nearly essential for all research scientists who aspire to lead a research laboratory in a university or non-profit research center. To characterize the transition of scientists from postdoc to established PI, we previously conducted an analysis of how many postdocs with a NIH-sponsored F32 fellowship went on to become PIs of a R-esearch grant. In 2006, NIH int...
Previously, we calculated the fraction of the R01 grant pool that each institution has obtained in 2013, and how this fraction has changed over time. We now wanted to perform a complementary analysis, determining institutional variability in the length of time that individual PIs are able to maintain NIH grant funding. This analysis would be of interest to university administrators who want to rec...
In our database, for any grant we report "Related Projects" that are renewals of ongoing projects from individual investigators. We wanted to improve this by identifying "Related Projects" more generally in which we group different grants based on the text in the abstract. We analyzed the similarities of 2013 NIH grant abstracts with lengths of at least 100 words (disregarding the public health r...
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