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The entirety of funding information.
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Role of Shp2 in FLT3-ITD-Induced LeukemogenesisAcute myeloid leukemia (AML) is a lethal disease which dramatically increases in incidence in individuals >65 years of age, the fastest growing population in the United States. Regrettably, the 5...
Phage mimicry of mycobacterial signalingMycobacterium tuberculosis is responsible for more human deaths than any other single infectious agent and imposes a considerable social and economic toll on a global scale. Adult pulmonary tuberculosis is...
Schwann cells, neurotrophins and spinal cord regrowthGlial cell line-derived neurotrophic factor (GDNF), a distant member of the transforming growth factor-beta (TGF-beta) family, is widely expressed in the developing and adult central nervous system (CNS). Limited knowledge...
Ecdysone Receptor Requirements in Drosophila DevelopmentHormone signaling is required in a variety of developmental processes in a host of animals, from insects to humans. Defects in hormones and their receptors are associated with many medical...
Chaperone-Assisted RNA CrystallographyBiological systems possess a highly complex and dynamic cellular RNA population, collectively known as the transcriptome. Many RNAs fold into complex three-dimensional structures, both intrinsically and as ribonucleoprotein (RNP) complexes,...
Intrarenal Arteries Sense N-formyl Peptides Leading to Vascular Injury in SepsisSystemic inflammatory response injury (SIRS) and sepsis are the principal causes of death in trauma patients in the USA. The diagnosis of sepsis requires confirmation of bacterial growth in blood...
Genetic and Molecular Dissection of Regulatory Mechanisms Underlying Temperature and Nutritional Compensation of the Circadian Clock in Neurospora crassaThe circadian clock serves a time-keeping function to anticipate daily changes in the environment and is used by almost every eukaryote on the planet. The ~24-hour circadian period length is...
Decoding the RNA Structurome: Method Development and Function Analysis.The long-term goal of my research is to comprehensively characterize the RNA structurome, here defined as the collection of all RNA structures and RNA-RNA interactions in living cells. RNA structures...
The postdoctoral training period is nearly essential for all research scientists who aspire to lead a research laboratory in a university or non-profit research center. To characterize the transition of scientists from postdoc to established PI, we previously conducted an analysis of how many postdocs with a NIH-sponsored F32 fellowship went on to become PIs of a R-esearch grant. In 2006, NIH int...
Previously, we calculated the fraction of the R01 grant pool that each institution has obtained in 2013, and how this fraction has changed over time. We now wanted to perform a complementary analysis, determining institutional variability in the length of time that individual PIs are able to maintain NIH grant funding. This analysis would be of interest to university administrators who want to rec...
In our database, for any grant we report "Related Projects" that are renewals of ongoing projects from individual investigators. We wanted to improve this by identifying "Related Projects" more generally in which we group different grants based on the text in the abstract. We analyzed the similarities of 2013 NIH grant abstracts with lengths of at least 100 words (disregarding the public health r...
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