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Indicated Treatment and Prevention of Marital Deterioration in At-Risk CouplesThe project objective is to conduct a Phase II clinical trial to study the efficacy and safety of the Marriage Checkup (MC), an indicated preventive intervention for treatment-avoidant couples at-risk...
Calcium Channel Subunit Regulation and Neuropathic PainThe long-term objective of this project is to investigate the molecular mechanism of neuropathic pain resulting from peripheral nerve injuries. These disorders do not typically respond to conventional analgesics, and...
Tace - an Upstream Regulator of Erbb Signaling Cellular Mechanisms of Drug Reactions in SchizophreniaThere are different HLA associations in patients with clozapine-induced agranulocytosis (CA): in Jewish patients, HLA-B38, DR4 (DRB1*0402, DQB1*0302, DQA1*0301, DPB1*0401), HSP70 9.0-A, and in non-Jewish patients, HLA-DR2 (DRB1*1602, DQB1*0502, DQA1*...
SCH: INT: Collaborative Research: Multimodal Signal Analysis and Data Fusion for Post-traumatic EpilepsyThe research objective of this proposal, Multimodal Signal Analysis and Data Fusion for Post-traumatic Epilepsy Prediction, with Pl Dominique Duncan from the University of Southern California, is to predict the...
Mechanisms of Functional Axon RegenerationA fundamental question in neurobiology is how axons respond to injury and disease. Damaged neurons can sometimes repair themselves by a process called axon regeneration. However, many neurons do not...
Spreading Depolarizations and Brain Dysfunction Following Traumatic Brain InjuryTraumatic brain injury (TBI) affects 2.8 million people in the US annually, but despite the heightened awareness and community interest in TBI, there are no effective interventions for TBI associated...
Functional Validation of Intracranial Aneurysm Risk GenesIntracranial aneurysms (IA) represent a significant health issue in the US and worldwide. Their rupture leads to intracranial hemorrhage, with devastating outcomes: 30% of patients with ruptured IA die within...
The postdoctoral training period is nearly essential for all research scientists who aspire to lead a research laboratory in a university or non-profit research center. To characterize the transition of scientists from postdoc to established PI, we previously conducted an analysis of how many postdocs with a NIH-sponsored F32 fellowship went on to become PIs of a R-esearch grant. In 2006, NIH int...
Previously, we calculated the fraction of the R01 grant pool that each institution has obtained in 2013, and how this fraction has changed over time. We now wanted to perform a complementary analysis, determining institutional variability in the length of time that individual PIs are able to maintain NIH grant funding. This analysis would be of interest to university administrators who want to rec...
In our database, for any grant we report "Related Projects" that are renewals of ongoing projects from individual investigators. We wanted to improve this by identifying "Related Projects" more generally in which we group different grants based on the text in the abstract. We analyzed the similarities of 2013 NIH grant abstracts with lengths of at least 100 words (disregarding the public health r...
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