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The entirety of funding information.
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Core B: Sample Preparation & Storage CoreThe goal of the Sample Preparation & Storage Core (Core B) is to standardize sample preparation, centralize sample storage and dispersion, and optimize the sharing of resources amongst each project...
(PQD1) Treatment-emergent resistance to NEDD8-activating enzyme inhibitionWe will test novel targeted strategies to modulate the emergence and evolution of drug resistance using the NEDD8-activating enzyme (NAE) inhibitor MLN4924. Aim 1 focuses on evaluating how treatment-associated on-target...
Type XI collagen isoforms in skeletal biologyCandidate: Dr. Julia Oxford has recently received an appointment to a tenure track position at Boise State University. She is trained in protein biochemistry and utilizes bioinformatic tools in her...
DNA Mismatch Repair in Transformation and MutagenesisThis project will investigate DNA base mismatch correction in Streptococcus pneumoniae. Such repair occurs after DNA-mediated genetic transformation and after potentially mutagenic base substitution in DNA replication. In transformation, single-site...
Chromosome Archae-tecture: Conserved principles of chromosome organizationThe three-dimensional organization of DNA within cells is of profound importance for the appropriate and timely execution of gene expression programs. Recent advances in experimental approaches have allowed the elucidation...
TAOK2 Kinase Signaling in Human Neural Stem Cell DevelopmentIncreasing evidence indicates that aberrations in neural stem cell proliferation and early neurogenesis are critically involved in the pathogenesis of neurodevelopmental and psychiatric disorders. Despite being implicated in pathophysiology of...
Circuit mechanisms of retrospective memory-linkingPost-traumatic stress disorder (PTSD) symptoms are often triggered by environmental stimuli that were not directly present during trauma, but which nevertheless elicit strong fear responses. Thus, understanding how fear spreads...
CPEB1 regulated synapse elimination by microgliaThe sequence-specific mRNA-binding protein CPEB1 (Cytoplasmic polyadenylation element-binding protein 1) regulates mRNA polyadenylation and translation and has been linked to defects in synaptic plasticity, learning, and memory. Synaptic connections...
The postdoctoral training period is nearly essential for all research scientists who aspire to lead a research laboratory in a university or non-profit research center. To characterize the transition of scientists from postdoc to established PI, we previously conducted an analysis of how many postdocs with a NIH-sponsored F32 fellowship went on to become PIs of a R-esearch grant. In 2006, NIH int...
Previously, we calculated the fraction of the R01 grant pool that each institution has obtained in 2013, and how this fraction has changed over time. We now wanted to perform a complementary analysis, determining institutional variability in the length of time that individual PIs are able to maintain NIH grant funding. This analysis would be of interest to university administrators who want to rec...
In our database, for any grant we report "Related Projects" that are renewals of ongoing projects from individual investigators. We wanted to improve this by identifying "Related Projects" more generally in which we group different grants based on the text in the abstract. We analyzed the similarities of 2013 NIH grant abstracts with lengths of at least 100 words (disregarding the public health r...
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