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Intestinal stem cell responses to ischemic injury in a large animal modelIntestinal mucosal epithelial injury compromises barrier function and can cause sepsis and death. Ischemia and the resulting hypoxia contribute significantly to epithelial damage in diseases such as neonatal necrotizing enterocolitis,...
Clinical Examination CenterARIC is a prospective epidemiologic study conducted in four U.S. communities: Washington County, MD; Forsyth County, NC; Jackson, MS; and Minneapolis, MN. The study is designed to monitor the trends...
Drug Development and Conservation of Biodiversity in WesWest-central Africa contains the largest moist equatorial forest on the continent, indeed the second largest continuous tropical rain-forest in the world (3 million square km). The species richness of this...
Parent/Professional Collaboration in Nicu DecisionsParental input into treatment decisions for their low birth weight infants in neonatal intensive care units (NICUs) is both a legal and ethical imperative. For parents to collaborate with health...
Obesity dysregulates immune and metabolic status in asthma and alters infection susceptibility.Asthma and obesity are two of the most common chronic diseases of childhood and are increasing in prevalence in the US and worldwide. Obesity and asthma are linked: as body...
Therapeutic Antibody for RSV IIBRespiratory syncytial virus (RSV) is a leading cause of serious lower respiratory tract disease in infants, leading annually to ~200,000 deaths and 3-4 million hospitalizations worldwide. Close to $1 billion...
Therapeutic activation of AMPK for the aging right heartThe overarching goal of this application is to provide Dr. Bruns the scientific and career development for a successful independent research career in the field of cardiac aging, with a...
Mechanisms of IL-33 secretion in allergic diseasesThe prevalence of allergic diseases and asthma is increasing worldwide. These diseases often occur together in the same individual, suggesting the presence of common underlying immunopathogenic factors. The long-term objective...
The postdoctoral training period is nearly essential for all research scientists who aspire to lead a research laboratory in a university or non-profit research center. To characterize the transition of scientists from postdoc to established PI, we previously conducted an analysis of how many postdocs with a NIH-sponsored F32 fellowship went on to become PIs of a R-esearch grant. In 2006, NIH int...
Previously, we calculated the fraction of the R01 grant pool that each institution has obtained in 2013, and how this fraction has changed over time. We now wanted to perform a complementary analysis, determining institutional variability in the length of time that individual PIs are able to maintain NIH grant funding. This analysis would be of interest to university administrators who want to rec...
In our database, for any grant we report "Related Projects" that are renewals of ongoing projects from individual investigators. We wanted to improve this by identifying "Related Projects" more generally in which we group different grants based on the text in the abstract. We analyzed the similarities of 2013 NIH grant abstracts with lengths of at least 100 words (disregarding the public health r...
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