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Outcomes Research in Rheumatic Diseases: A Mentoring ProgramThe aim of this application is to develop a patient-oriented mentoring and research program in rheumatic diseases at Baylor College of Medicine. By establishing a comprehensive methodological and content-based program...
Cellular Roles in Liver Pathology: Dioxin as Prototype Presynaptic Receptors on Embryonic Sensory NeuronsVoltage-dependent Ca2+ channels have evolved to regulate physiological processes as diverse as gene transcription and muscle contraction. In the central nervous system, several structurally and pharmacologically distinct Ca2+ channel types...
Lipoprotein Metabolism in the Extravascular SpaceRecent findings in my laboratory have provided a potential link between the normal response to inflammatory stimuli and mechanisms which may inititate the atherosclerotic process. The modifications which we have...
Project 2: Extracellular Glycosylation and Blood Cell ProductionMaintaining hematopoiesis is critical for life. Generating the proper numbers of functional blood cells across all lineages requires cell-intrinsic developmental programs, but these programs require guidance from cell-extrinsic mechanisms that...
Project 3: Role of Glycosaminoglycans in HematopoiesisGlycosaminoglycans (GAGs) contribute to myriad, and very often opposing, functions such as cellular proliferation as well as apoptosis, self-renewal as well as differentiation. Yet, precious little is understood about the...
Cancer Center Support GrantOVERALL - ABSTRACT The Karmanos Cancer Institute (KCI), founded in 1943, is a not-for-profit, cancer-only research and patient care organization in partnership with Wayne State University (WSU) in Michigan. The...
Cancer Center AdministrationCANCER CENTER ADMINISTRATION - ABSTRACT Administration at the Karmanos Cancer Institute (KCI) provides support to the Cancer Center leadership, Research Program and Shared Resource infrastructure, KCI membership, and staff by...
The postdoctoral training period is nearly essential for all research scientists who aspire to lead a research laboratory in a university or non-profit research center. To characterize the transition of scientists from postdoc to established PI, we previously conducted an analysis of how many postdocs with a NIH-sponsored F32 fellowship went on to become PIs of a R-esearch grant. In 2006, NIH int...
Previously, we calculated the fraction of the R01 grant pool that each institution has obtained in 2013, and how this fraction has changed over time. We now wanted to perform a complementary analysis, determining institutional variability in the length of time that individual PIs are able to maintain NIH grant funding. This analysis would be of interest to university administrators who want to rec...
In our database, for any grant we report "Related Projects" that are renewals of ongoing projects from individual investigators. We wanted to improve this by identifying "Related Projects" more generally in which we group different grants based on the text in the abstract. We analyzed the similarities of 2013 NIH grant abstracts with lengths of at least 100 words (disregarding the public health r...
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