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The entirety of funding information.
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Investigating CREBBP as a tumor suppressor in small cell lung cancerSmall cell lung cancer (SCLC) is a neuroendocrine cancer of the lung with dismal survival rates. There are no therapies for SCLC directed towards tumors harboring specific driver mutations. Recent...
Randomized trial of sertraline treatment of depression in Chronic Kidney DiseaseDepression is common in those on dialysis and is an independent risk factor for hospitalization and death. Recent studies from my laboratory have shown that about 20% of patients with...
ECM and the Differentiation/Plasticity of DA Neurons: We have recently shown in animal models of Parkinson's disease, a progressive neurodegenerative disorder characterized by the degeneration of nigrostriatal dopaminergic neurons, that there is a robust proliferative burst...
Binding of Klebsiella Fimbriae to Respiratory TissueThe type 3 fimbrial adhesin (MrkD) of Klebsiella pneumoniae mediates binding of the bacteria to specific types of collagen. The receptors for this adhesin molecule are located in the basement...
Hypertension and inflammation: novel insights from human angiotensin type 1 receptor variantsAngiotensin II (Ang II) contributes to the pathophysiological consequences of vascular and renal systems and angiotensin receptor type 1 (AT1R) mediates these effects. AT1R-signaling promotes renal sodium retention, vascular remodeling,...
Epigenomic basis of resilience to heart failureEpigenomic features centrally underpin cardiovascular health. Among these, DNA methylation has emerged as a stable, but not immutable, chromatin modification that can be associated with gene expression but yet decorates...
Hypothalamic astrocyte-neuron relationship links overnutrition to hypertensionObesity-related hypertension (OHT), an etiologically prevalent disorder accounting for ~75% of patients with hypertension, is however hard to control, and this clinical difficulty is related to the specific yet much...
HIV Center for Clinical and Behavioral StudiesPromising new tools for HIV prevention and treatment have stimulated global initiatives to ?End the HIV Epidemic? and reach the ?End of AIDS;? however, significant challenges to ending the global...
The postdoctoral training period is nearly essential for all research scientists who aspire to lead a research laboratory in a university or non-profit research center. To characterize the transition of scientists from postdoc to established PI, we previously conducted an analysis of how many postdocs with a NIH-sponsored F32 fellowship went on to become PIs of a R-esearch grant. In 2006, NIH int...
Previously, we calculated the fraction of the R01 grant pool that each institution has obtained in 2013, and how this fraction has changed over time. We now wanted to perform a complementary analysis, determining institutional variability in the length of time that individual PIs are able to maintain NIH grant funding. This analysis would be of interest to university administrators who want to rec...
In our database, for any grant we report "Related Projects" that are renewals of ongoing projects from individual investigators. We wanted to improve this by identifying "Related Projects" more generally in which we group different grants based on the text in the abstract. We analyzed the similarities of 2013 NIH grant abstracts with lengths of at least 100 words (disregarding the public health r...
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