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Heteroresistance Interdisciplinary Research Unit (Admin Core)The broad objective of the Administrative Core is to provide infrastructure for the effective operation of the Heteroresistance Interdisciplinary Research Unit (HR-IRU) by facilitating synergistic and productive interactions amongst the...
Biomarkers for Molecular-Based Decision-Making in Diagnosis and Treatment of InteInterstitial cystitis/painful bladder syndrome/bladder pain syndrome (IC/PBS/BPS; hereafter IC) is a vexing and heterogeneous lower urinary tract disorder, currently defined by the International Continence Society as: an unpleasant sensation (pain,...
Pathophysiology of Mptp ParkinsoniansIn spite of major advances made in the past 20 years concerning the pathological anatomy, biochemical abnormalities and treatment of Parkinson's disease (PD), the pathophysiology of this disorder and how...
U.S.-Italy Cooperative Workshop: Support to Attend the 1998 Three Dimensional Modeling of Seismic Waves Generation, Propagation and Their Inversion, Trieste, Italy, 9/28-10/9/98This one-year award will support participation of eight US students to attend workshops on "Three-Dimensional Modeling of Seismic Waves Generation, Propagation and Their Inversion," to be held at the International...
Project 3: Rodent Studies of Anesthetic ActionPROJECT 3: RODENT STUDIES OF ANESTHETIC ACTION General anesthesia is a fascinating man-made, neurophysiological phenomenon that has been developed empirically over many years to enable safe and humane performance of...
Coupled Emission Microscopy for the BiosciencesFluorescence imaging is used widely in almost all the biosciences. Examples include imaging of microscope slides with spots of DNA or proteins, multiplexed assays of classes of molecules like cytokines...
Scaling of transcript abundance with cell size and the commitment to cell divisionAll cells must grow to a minimum size?the ?critical size??before they can commit to cell division. This size requirement prevents cells from becoming too big or too small, and it...
Lipid signaling in Hippo pathway regulationOverthepastdecades,theHippopathwayhasbeenrecognizedasacrucialsignalingpathwaythat controlsorganandtissuesize,byrestrictingcellproliferationandanti-apoptosis.TheHippopathwaycanbe regulatedbyawiderangeofextracellularsignaling,includingperceivedphysical...
The postdoctoral training period is nearly essential for all research scientists who aspire to lead a research laboratory in a university or non-profit research center. To characterize the transition of scientists from postdoc to established PI, we previously conducted an analysis of how many postdocs with a NIH-sponsored F32 fellowship went on to become PIs of a R-esearch grant. In 2006, NIH int...
Previously, we calculated the fraction of the R01 grant pool that each institution has obtained in 2013, and how this fraction has changed over time. We now wanted to perform a complementary analysis, determining institutional variability in the length of time that individual PIs are able to maintain NIH grant funding. This analysis would be of interest to university administrators who want to rec...
In our database, for any grant we report "Related Projects" that are renewals of ongoing projects from individual investigators. We wanted to improve this by identifying "Related Projects" more generally in which we group different grants based on the text in the abstract. We analyzed the similarities of 2013 NIH grant abstracts with lengths of at least 100 words (disregarding the public health r...
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