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The entirety of funding information.
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Role of inflammation in resistance to EGFR inhibitors in head and neck cancerAcquired resistance and poor tumor response to epidermal growth factor receptor (EGFR) inhibitors is a significant challenge for effective treatment of head and neck squamous cell carcinoma (HNSCC). Therefore, further...
Molecular Pathogenesis of Parathyroid NeoplasiaSpecifically, the long-term objective of the proposed research is to identify and characterize genes that are important in the pathogenesis of human parathyroid neoplasms (both adenomas and carcinomas). Although the...
Early Intervention B.A.N.A. Youth Action Project
Irregular Wave Reflection, Runup and Armor Movement on RoughPermeable Slopes of Breakwaters and RevetmentsA theoretical model, and experimental simulations in a wave tank, will be constructed and applied to the problem of wave run-up and damage on breakwaters. A prior numerical model developed...
Role of virus-receptor interactions in determining norovirus tropism and pathogenesis in vivoThis proposal describes a five-year career development program for the PI, Craig Wilen, M.D., Ph.D. to with the goal of preparing him for an independent research career as an academic...
Development of Novel Therapeutics for LeishmaniasisRelevance. Leishmania parasites infect an estimated 12 million individuals, and no satisfactory treatments are yet available. This proposal will advance 3 scaffolds that have emerged from a phenotypic screen for...
A systems analysis of drug tolerance in Mycobacterium tuberculosisThis project will address the critical need for new and effective antitubercular drugs. Our primary objective is to elucidate the mechanisms by which Mycobacterium tuberculosis tolerates antitubercular drug treatment. Our...
Glucose and Amino Acid Catabolism in Plasma Cell BiologyThe usage of metabolic pathways is tailored to meet the specific functions and demands of a given cell type. Of particular interest is how metabolism supports the survival and antibody...
The postdoctoral training period is nearly essential for all research scientists who aspire to lead a research laboratory in a university or non-profit research center. To characterize the transition of scientists from postdoc to established PI, we previously conducted an analysis of how many postdocs with a NIH-sponsored F32 fellowship went on to become PIs of a R-esearch grant. In 2006, NIH int...
Previously, we calculated the fraction of the R01 grant pool that each institution has obtained in 2013, and how this fraction has changed over time. We now wanted to perform a complementary analysis, determining institutional variability in the length of time that individual PIs are able to maintain NIH grant funding. This analysis would be of interest to university administrators who want to rec...
In our database, for any grant we report "Related Projects" that are renewals of ongoing projects from individual investigators. We wanted to improve this by identifying "Related Projects" more generally in which we group different grants based on the text in the abstract. We analyzed the similarities of 2013 NIH grant abstracts with lengths of at least 100 words (disregarding the public health r...
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