""""""""Overpopulation is a major concern for the future of Brazil, China and the entire world because of its adverse effects on the health and well-being of humans resulting from poverty, malnutrition, disease, environmental pollution and destruction of natural resources. We address the overpopulation problem through biological research to develop a new and effective method for male contraception.? The Laboratories for Reproductive Biology at the University of North Carolina School of Medicine at Chapel Hill is participating in an international collaborative network together with the following foreign laboratories: 1) Section of Experimental Pharmacology, Department of Pharmacology, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Brazil, 2) Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute for Biological Sciences and 3) The Laboratory of Reproductive Medicine, Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. ? Network activities include: 1) research collaborations 2) research training for predoctoral and postdoctoral students 3) exchange visits by participating faculty members and trainees for research discussions, seminars, and workshops. ? The program will produce new investigators and advances in research to increase our knowledge of how spermatozoa acquire fertilizing ability and will use this information to develop a new and improved method of male contraception. ? Ultimately, the goal of our research is to help solve the global problem of overpopulation and its multiple adverse effects on the health and well being of humans.? """"""""? ? ? ? ?

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Training Grants (D43)
Project #
5D43TW000627-12
Application #
7290349
Study Section
Special Emphasis Panel (ZRG1-BDA-A (90))
Program Officer
Mcdermott, Jeanne
Project Start
1995-09-30
Project End
2011-03-31
Budget Start
2007-04-01
Budget End
2008-03-31
Support Year
12
Fiscal Year
2007
Total Cost
$173,402
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Pediatrics
Type
Schools of Medicine
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Danshina, Polina V; Qu, Weidong; Temple, Brenda R et al. (2016) Structural analyses to identify selective inhibitors of glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzyme. Mol Hum Reprod 22:410-26
Li, Xiangqi; Zhan, Xiaoni; Liu, Shigui et al. (2012) Cloning and primary characterizations of rLcn9, a new member of epididymal lipocalins in rat. Acta Biochim Biophys Sin (Shanghai) 44:876-85
Liu, Qiang; Su, Shifeng; Blackwelder, Amanda J et al. (2011) Gain in transcriptional activity by primate-specific coevolution of melanoma antigen-A11 and its interaction site in androgen receptor. J Biol Chem 286:29951-63
Hu, Shuanggang; Yao, Guangxin; Guan, Xiaojun et al. (2010) Research resource: Genome-wide mapping of in vivo androgen receptor binding sites in mouse epididymis. Mol Endocrinol 24:2392-405
O'Rand, M G; Widgren, E E; Wang, Zengjun et al. (2007) Eppin: an epididymal protease inhibitor and a target for male contraception. Soc Reprod Fertil Suppl 63:445-53
Wang, Zengjun; Widgren, E E; Richardson, R T et al. (2007) Eppin: a molecular strategy for male contraception. Soc Reprod Fertil Suppl 65:535-42
Yenugu, Suresh; Chintalgattu, Vishnu; Wingard, Christopher J et al. (2006) Identification, cloning and functional characterization of novel beta-defensins in the rat (Rattus norvegicus). Reprod Biol Endocrinol 4:7
Radhakrishnan, Y; Hamil, K G; Yenugu, S et al. (2005) Identification, characterization, and evolution of a primate beta-defensin gene cluster. Genes Immun 6:203-10
Wang, Zengjun; Widgren, E E; Sivashanmugam, P et al. (2005) Association of eppin with semenogelin on human spermatozoa. Biol Reprod 72:1064-70
Jeyaraj, D Antony; Grossman, Gail; Petrusz, Peter (2005) Altered bioavailability of testosterone in androgen-binding protein-transgenic mice. Steroids 70:704-14

Showing the most recent 10 out of 24 publications