This supplement is designed to marry the resources of the UNC AITRP, the UNC CFAR, and the Johns Hopkins/UNC HIVNET. UNC investigators have developed a research and training infrastructure at Lilongwe Central Hospital in Malawi. However, the laboratory capacity is rudimentary. Through our combined resources we propose to develop improved laboratory capacity/infrastructure which will allow research to be conducted in-country, and greatly expand the capacity for """"""""bidirectional"""""""" training. In the first Aim of this proposal UNC investigators will transfer technologies required for laboratory expansion to Malawi. In the second Aim of this Proposal specific critical assays will be established. These include: i) quantification of HIV RNA in both blood and genital secretions; ii) development of a detuned ELISA specific to Clade C that will allow us to detect early infection in Malawi; iii) development of a """"""""full-service"""""""" STD laboratory that will allow detection of both mucosal inflammatory pathogens and pathogens that cause genital ulcers. In the third Aim of this Proposal the expanded laboratory capacity will be used to increase short and long-term in-country training, and allow UNC students to train in Malawi as well. We expect the expanded laboratory capacity proposed to enhance research, training and clinical care in Malawi.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Training Grants (D43)
Project #
5D43TW001039-05
Application #
6540754
Study Section
Special Emphasis Panel (ZAI1-SCO-F (S1))
Program Officer
Mcdermott, Jeanne
Project Start
1998-09-30
Project End
2004-05-31
Budget Start
2002-06-01
Budget End
2004-05-31
Support Year
5
Fiscal Year
2002
Total Cost
$894,095
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
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