This supplement is designed to marry the resources of the UNC AITRP, the UNC CFAR, and the Johns Hopkins/UNC HIVNET. UNC investigators have developed a research and training infrastructure at Lilongwe Central Hospital in Malawi. However, the laboratory capacity is rudimentary. Through our combined resources we propose to develop improved laboratory capacity/infrastructure which will allow research to be conducted in-country, and greatly expand the capacity for """"""""bidirectional"""""""" training. In the first Aim of this proposal UNC investigators will transfer technologies required for laboratory expansion to Malawi. In the second Aim of this Proposal specific critical assays will be established. These include: i) quantification of HIV RNA in both blood and genital secretions; ii) development of a detuned ELISA specific to Clade C that will allow us to detect early infection in Malawi; iii) development of a """"""""full-service"""""""" STD laboratory that will allow detection of both mucosal inflammatory pathogens and pathogens that cause genital ulcers. In the third Aim of this Proposal the expanded laboratory capacity will be used to increase short and long-term in-country training, and allow UNC students to train in Malawi as well. We expect the expanded laboratory capacity proposed to enhance research, training and clinical care in Malawi.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Training Grants (D43)
Project #
5D43TW001039-05
Application #
6540754
Study Section
Special Emphasis Panel (ZAI1-SCO-F (S1))
Program Officer
Mcdermott, Jeanne
Project Start
1998-09-30
Project End
2004-05-31
Budget Start
2002-06-01
Budget End
2004-05-31
Support Year
5
Fiscal Year
2002
Total Cost
$894,095
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Ewing, Alexander C; Ellington, Sascha R; Wiener, Jeffrey B et al. (2018) Predictors of Perinatal HIV Transmission Among Women Without Prior Antiretroviral Therapy in a Resource-Limited Setting: The BAN Study. Pediatr Infect Dis J :
Hampel, Daniela; Shahab-Ferdows, Setareh; Gertz, Erik et al. (2018) The effects of a lipid-based nutrient supplement and antiretroviral therapy in a randomized controlled trial on iron, copper, and zinc in milk from HIV-infected Malawian mothers and associations with maternal and infant biomarkers. Matern Child Nutr 14:e12503
Chevalier, Michelle S; King, Caroline C; Ellington, Sascha et al. (2017) Maternal and neonatal outcomes among women with HIV infection and their infants in Malawi. Int J Gynaecol Obstet 137:282-289
Ewing, Alexander C; King, Caroline C; Wiener, Jeffrey B et al. (2017) Effects of concurrent exposure to antiretrovirals and cotrimoxazole prophylaxis among HIV-exposed, uninfected infants. AIDS 31:2455-2463
Zadrozny, Sabrina; Westreich, Daniel; Hudgens, Michael G et al. (2017) Effect of Postnatal HIV Treatment on Clinical Mastitis and Breast Inflammation in HIV-Infected Breast-feeding Women. Paediatr Perinat Epidemiol 31:134-143
Chagomerana, Maganizo B; Miller, William C; Pence, Brian W et al. (2017) PMTCT Option B+ Does Not Increase Preterm Birth Risk and May Prevent Extreme Prematurity: A Retrospective Cohort Study in Malawi. J Acquir Immune Defic Syndr 74:367-374
Davis, Nicole L; Miller, William C; Hudgens, Michael G et al. (2016) Maternal and Breast Milk Viral Load: Impacts of Adherence on Peri-Partum HIV Infections Averted - the BAN Study. J Acquir Immune Defic Syndr :
Hampel, Daniela; Shahab-Ferdows, Setareh; Adair, Linda S et al. (2016) Thiamin and Riboflavin in Human Milk: Effects of Lipid-Based Nutrient Supplementation and Stage of Lactation on Vitamer Secretion and Contributions to Total Vitamin Content. PLoS One 11:e0149479
Davis, Nicole L; Miller, William C; Hudgens, Michael G et al. (2016) Maternal and Breastmilk Viral Load: Impacts of Adherence on Peripartum HIV Infections Averted-The Breastfeeding, Antiretrovirals, and Nutrition Study. J Acquir Immune Defic Syndr 73:572-580
Sanders, Eduard J; Wahome, Elizabeth; Powers, Kimberly A et al. (2015) Targeted screening of at-risk adults for acute HIV-1 infection in sub-Saharan Africa. AIDS 29 Suppl 3:S221-30

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