The continuing goal for this program is the training of clinicians, nurses, scientists, laboratory technicians and social workers from India, Cameroon, and China in the prevention, diagnosis, and treatment of HIV and TB infections. This multidisciplinary program includes the participation of public and private universities, hospitals, and non-governmental organizations that provide services designed to improve the health and well-being of the populations they serve. The institutions with which the NYU AITRP proposes to collaborate nclude 3 in India (the Post Graduate Institute for Medical Research and Education [Chandigarh], the All India Institute of Medical Sciences [NewDelhi] and King Edward Memorial Hospital [Mumbai]), 2 in Cameroon (Alpha Royal Clinic [Bamenda] and the Laboratoire de Sante Hygiene [Yaounde]), and 3 in China (the Shanghai CDC, the Shanghai Public Health Center and the Shanghai Medical College of Fudan University [Shanghai]). During the proposed funding cycle, training of candidates will be tailored to the needs of each specific country and those of the institutions involved. Thus, while all 3 countries face escalating HIV and TB epidemics, our partner institutions in India and China possess much of the scientific talent and infrastructure to conduct applied, basic scientific, and/or clinical research designed to improve prevention, diagnosis and treatment of HIV and TB. In contrast, most institutions in Cameroon lack the trained manpower and infrastructure to conduct such work. Consequently, the proposed training at our partner institutions in India and China aims to foster collaborative research and clinical studies between the participating institutions and with NYU; our goal is to supply the training needed to initiate and continue relevant research by providing intellectual support for planning and execution of projects and for obtaining funding for further studies. For Cameroon, our training will focus on supporting local AIDS control programs; we will focus on teaching technical skills and on the development within the available infrastructure to design and implement relevant programs in the prevention, diagnosis, and treatment of HIV and TB. While the details of the program differ between the sites and countries, the overall goals are the same for each: 1) to establish critical biomedical, laboratory and clinical science expertise; 2) to facilitate new research efforts, which will complement the ongoing research at NYU, aimed at prevention, diagnosis and treatment of HIV and HIV-related diseases, especially TB; 3) to establish long-term collaborative relationships between scientists at NYU and our partner institutions in India, Cameroon, and China; and 4) to integrate the training into ongoing prevention, diagnosis and treatment research efforts in the 3 countries. The goals of this program will be achieved through long- and short-term training at NYU and through training workshops and seminars at our partner institutions.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Training Grants (D43)
Project #
3D43TW001409-07S1
Application #
7499460
Study Section
Special Emphasis Panel (ZRG1-ICP2-B (51))
Program Officer
Mcdermott, Jeanne
Project Start
2000-09-30
Project End
2011-05-31
Budget Start
2007-06-01
Budget End
2008-05-31
Support Year
7
Fiscal Year
2007
Total Cost
$107,600
Indirect Cost
Name
New York University
Department
Pathology
Type
Schools of Medicine
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016
Singhal, Ritu; Reynolds, Paul R; Marola, Jamie L et al. (2016) Sequence Analysis of Fluoroquinolone Resistance-Associated Genes gyrA and gyrB in Clinical Mycobacterium tuberculosis Isolates from Patients Suspected of Having Multidrug-Resistant Tuberculosis in New Delhi, India. J Clin Microbiol 54:2298-305
Ryndak, Michelle B; Singh, Krishna K; Peng, Zhengyu et al. (2015) Transcriptional profile of Mycobacterium tuberculosis replicating in type II alveolar epithelial cells. PLoS One 10:e0123745
Verma, Ajoy Kumar; Kumar, Gavish; Arora, Jyoti et al. (2015) Identification of mycobacterial species by PCR restriction enzyme analysis of the hsp65 gene—an Indian experience. Can J Microbiol 61:293-6
Ryndak, Michelle B; Singh, Krishna K; Peng, Zhengyu et al. (2015) Transcriptional Profiling of Mycobacterium tuberculosis Replicating in the Human Type II Alveolar Epithelial Cell Line, A549. Genom Data 5:112-114
Agyingi, Lucy; Mayr, Luzia M; Kinge, Thompson et al. (2014) The evolution of HIV-1 group M genetic variability in Southern Cameroon is characterized by several emerging recombinant forms of CRF02_AG and viruses with drug resistance mutations. J Med Virol 86:385-93
Ryndak, Michelle B; Singh, Krishna K; Peng, Zhengyu et al. (2014) Transcriptional profiling of Mycobacterium tuberculosis replicating ex vivo in blood from HIV- and HIV+ subjects. PLoS One 9:e94939
Mayr, Luzia M; Powell, Rebecca L; Ngai, Johnson N et al. (2012) Superinfection by discordant subtypes of HIV-1 does not enhance the neutralizing antibody response against autologous virus. PLoS One 7:e38989
Agarwal, Ritesh; Gupta, Dheeraj; Srinivas, Rajagopala et al. (2012) Analysis of humoral responses to proteins encoded by region of difference 1 of Mycobacterium tuberculosis in sarcoidosis in a high tuberculosis prevalence country. Indian J Med Res 135:920-3
Hioe, Catarina E; Tuen, Michael; Vasiliver-Shamis, Gaia et al. (2011) HIV envelope gp120 activates LFA-1 on CD4 T-lymphocytes and increases cell susceptibility to LFA-1-targeting leukotoxin (LtxA). PLoS One 6:e23202
Burda, Sherri T; Viswanath, Ragupathy; Zhao, Jiangqin et al. (2010) HIV-1 reverse transcriptase drug-resistance mutations in chronically infected individuals receiving or naïve to HAART in Cameroon. J Med Virol 82:187-96

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