This is a competitive renewal application from the University of Maryland and the University of Bamako, Mali for continued support for the FIC training program, Malaria Research Training in Mali. The overall goal of the program is to build sustainable research capacity at the Malaria Research and Training Center (MRTC) at the University of Bamako, Mali. This will be accomplished by continuing to provide training in malaria research to junior scientists at the MRTC, filling identified gaps in expertise and capacity at the MRTC, and strengthening the sustainability of malaria research in Mali by developing the ability of MRTC scientists to compete for research funding. The ultimate result of this training will be to benefit the public health of Mali. The University of Maryland and the University of Bamako have worked in close partnership for ten years on studies of malaria drug resistance, pathogenesis, immunity, epidemiology, genetics and clinical trials of vaccines and drugs. This successful research partnership has helped create a rich environment for training Malian malaria researchers for the last five years. The Malaria Training Grant has provided opportunities for dozens of MRTC scientists, including short-term training in the U.S. and Mali, and long-term degree training based in at the University of Bamako. We propose to maintain and extend this successful training program, adding a bioinformatics component emphasizing applied genomics research. Research training will emphasize priority research areas including clinical trials of malaria vaccines and combination drug therapies and malaria in pregnancy. To meet the needs of the MRTC to develop in-house expertise in bioinformatics, including the ability to manage and analyze genomic scale datasets, one MRTC researcher will undertake PhD training in bioinformatics at the University of Pennsylvania Genomics Institute. ? ? ?

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Training Grants (D43)
Project #
2D43TW001589-06
Application #
7124039
Study Section
Special Emphasis Panel (ZRG1-ICP2-B (50))
Program Officer
Sina, Barbara J
Project Start
2000-09-29
Project End
2011-03-31
Budget Start
2006-09-08
Budget End
2007-03-31
Support Year
6
Fiscal Year
2006
Total Cost
$134,660
Indirect Cost
Name
University of Maryland Baltimore
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
188435911
City
Baltimore
State
MD
Country
United States
Zip Code
21201
Niangaly, Amadou; Karthigayan Gunalan; Amed Ouattara et al. (2017) Plasmodium vivax Infections over 3 Years in Duffy Blood Group Negative Malians in Bandiagara, Mali. Am J Trop Med Hyg 97:744-752
Dara, Antoine; Travassos, Mark A; Adams, Matthew et al. (2017) A new method for sequencing the hypervariable Plasmodium falciparum gene var2csa from clinical samples. Malar J 16:343
Dara, Antoine; Drábek, Elliott F; Travassos, Mark A et al. (2017) New var reconstruction algorithm exposes high var sequence diversity in a single geographic location in Mali. Genome Med 9:30
Graves, Shawna F; Kouriba, Bourema; Diarra, Issa et al. (2016) Strain-specific Plasmodium falciparum multifunctional CD4(+) T cell cytokine expression in Malian children immunized with the FMP2.1/AS02A vaccine candidate. Vaccine 34:2546-55
Sobota, Rafal S; Dara, Antoine; Manning, Jessica E et al. (2016) Expression of complement and toll-like receptor pathway genes is associated with malaria severity in Mali: a pilot case control study. Malar J 15:150
Nabet, Cécile; Doumbo, Safiatou; Jeddi, Fakhri et al. (2016) Genetic diversity of Plasmodium falciparum in human malaria cases in Mali. Malar J 15:353
Malaria Genomic Epidemiology Network; Band, Gavin; Rockett, Kirk A et al. (2015) A novel locus of resistance to severe malaria in a region of ancient balancing selection. Nature 526:253-7
Travassos, Mark A; Coulibaly, Drissa; Bailey, Jason A et al. (2015) Differential recognition of terminal extracellular Plasmodium falciparum VAR2CSA domains by sera from multigravid, malaria-exposed Malian women. Am J Trop Med Hyg 92:1190-4
Bailey, Jason A; Pablo, Jozelyn; Niangaly, Amadou et al. (2015) Seroreactivity to a large panel of field-derived Plasmodium falciparum apical membrane antigen 1 and merozoite surface protein 1 variants reflects seasonal and lifetime acquired responses to malaria. Am J Trop Med Hyg 92:9-12
Ouattara, Amed; Kone, Aminatou; Adams, Matthew et al. (2015) Polymorphisms in the K13-propeller gene in artemisinin-susceptible Plasmodium falciparum parasites from Bougoula-Hameau and Bandiagara, Mali. Am J Trop Med Hyg 92:1202-6

Showing the most recent 10 out of 33 publications