This is a competing renewal application for a Fogarty International Center-sponsored Global Infectious Disease Research Training Program in vaccine development and public health between the International Centre for Diarrhoeal Research in Dhaka, Bangladesh (ICDDR,B) and the Massachusetts General Hospital (MGH) in Boston, Massachusetts. Now in its 10th year, this training program has focused on long-term training of young investigators at the ICDDR,B. In this renewal application, we propose to focus on in-country training in Bangladesh, to include training tracks in both laboratory sciences and public health investigation, and to include trainees at a range of career development stages. The research platform upon which training would occur is based upon active and successful NIH and other collaborative projects between the co-program directors for this training program, Dr. Firdausi Qadri, Head of the Immunology Unit in the Laboratory Science Division at the ICDDR,B, and Dr. Edward Ryan, Division of Infectious Diseases, Massachusetts General Hospital. These co-program directors collaborate closely on a number of research projects, including a NIAID-sponsored International Collaborations in Infectious Disease Research (ICIDR) award focusing on evaluating protective immunity during cholera, and a NIAID-sponsored U01 project appplying high throughput technologies to Vibrio cholerae infection and vaccine development. We propose to train individuals through both degree and non-degree programs, the former through collaborative arrangements with the James P. Grant School of Public Health-BRAC University in Dhaka, Bangladesh (Masters of Public Health Program), and in focused laboratory research to support Masters of Science and Ph.D. degree candidacy in Biochemistry and Molecular Biology, Dhaka University. We also propose to include long-term non-degree granting training, including post- masters (in Dhaka and Boston) and post-doctoral fellowship training (in Dhaka). We have assembled faculty with expertise in laboratory sciences, infectious diseases and public health, and the goal of this program would be to meet research and public health needs at the ICDDR,B through individual and institutional capacity building.

Public Health Relevance

This is a competing renewal application for a Fogarty International Center-sponsored Global Infectious Disease Research Training Program in vaccine development and public health between the International Centre for Diarrhoeal Disease Research in Dhaka, Bangladesh (ICDDR,B), and the Massachusetts General Hospital (MGH) in Boston. The program would focus on long-term training in laboratory sciences and public health, would include both degree and non-degree programs, and would provide individual and institutional capacity building at the ICDDR,B. The program would build upon ongoing and active scientific collaborations between the ICDDR,B and MGH on Vibrio cholerae, enteric infection, and vaccine development and evaluation.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Training Grants (D43)
Project #
5D43TW005572-14
Application #
8703188
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Sina, Barbara J
Project Start
2000-09-29
Project End
2016-07-31
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
14
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Sayeed, Md Abu; Islam, Kamrul; Hossain, Motaher et al. (2018) Development of a new dipstick (Cholkit) for rapid detection of Vibrio cholerae O1 in acute watery diarrheal stools. PLoS Negl Trop Dis 12:e0006286
Islam, Kamrul; Hossain, Motaher; Kelly, Meagan et al. (2018) Anti-O-specific polysaccharide (OSP) immune responses following vaccination with oral cholera vaccine CVD 103-HgR correlate with protection against cholera after infection with wild-type Vibrio cholerae O1 El Tor Inaba in North American volunteers. PLoS Negl Trop Dis 12:e0006376
Bhuiyan, Taufiqur Rahman; Hoq, Mohammad Rubel; Nishat, Naoshin Sharmin et al. (2018) Assessing antigen specific HLA-DR+ antibody secreting cell (DR+ASC) responses in whole blood in enteric infections using an ELISPOT technique. Microbes Infect 20:122-129
Aktar, Amena; Rahman, M Arifur; Afrin, Sadia et al. (2018) Plasma and memory B cell responses targeting O-specific polysaccharide (OSP) are associated with protection against Vibrio cholerae O1 infection among household contacts of cholera patients in Bangladesh. PLoS Negl Trop Dis 12:e0006399
Bourque, Daniel L; Bhuiyan, Taufiqur Rahman; Genereux, Diane P et al. (2018) Analysis of the Human Mucosal Response to Cholera Reveals Sustained Activation of Innate Immune Signaling Pathways. Infect Immun 86:
Andrews, Jason R; Khanam, Farhana; Rahman, Nazia et al. (2018) Plasma IgA responses against two Salmonella Typhi antigens identify patients with typhoid fever. Clin Infect Dis :
Domman, Daryl; Chowdhury, Fahima; Khan, Ashraful I et al. (2018) Defining endemic cholera at three levels of spatiotemporal resolution within Bangladesh. Nat Genet 50:951-955
Park, Ki Soo; Kim, Hoyoung; Kim, Soojin et al. (2017) Nanomagnetic System for Rapid Diagnosis of Acute Infection. ACS Nano 11:11425-11432
Charles, Richelle C; Nakajima, Rie; Liang, Li et al. (2017) Plasma and Mucosal Immunoglobulin M, Immunoglobulin A, and Immunoglobulin G Responses to the Vibrio cholerae O1 Protein Immunome in Adults With Cholera in Bangladesh. J Infect Dis 216:125-134
Kauffman, Robert C; Bhuiyan, Taufiqur R; Nakajima, Rie et al. (2016) Single-Cell Analysis of the Plasmablast Response to Vibrio cholerae Demonstrates Expansion of Cross-Reactive Memory B Cells. MBio 7:

Showing the most recent 10 out of 87 publications