In this application, we propose to establish the University of Pittsburgh International Malaria Training and Research Program (IMTRP) by forging a strong alliance with Kenyatta University in Nairobi, Kenya, to study severe malaria anemia (SMA) in children. The objective of this program is to train local scientists that operate independently within Kenya to face the overwhelming morbidity and mortality placed on the Kenya people by SMA. The superb training and enabling environment at the University of Pittsburgh in the Graduate School of Public Health and Kenyatta University at the Centre for Complementary Medicine and Biotechnology (CCMB), respectively, including our strong collaborative ties with key institutions and researchers in Kenya, will facilitate the accomplishment of this goal. Over the course of this 4 year training program, we propose to train one postdoctoral fellow and two doctoral students at the University of Pittsburgh. The field-research will take place in Kisuma, Kenya, a holoendemic area of malaria transmission in western Kenya. In this area, the primary presentation of complicated malaria is severe malarial anemia with the highest frequency predominating in children under two years of age. In addition, a re-entry grant will be incorporated into the program to enable Kenyan scientist(s) to set-up/upgrade laboratory infrastructure at the CCMB and contribute to research activities therein. In years 1 and 3 of the project, we shall hold a three-week short-term intensive training course on infectious disease control including Immunology, Genetics, Hermatology, Epidemiology, and Biostatistics. The course will be held at Kenyatta University and will be taught by researchers from Kenya and the US. The overall project we have assembled, will ensure that all participants in the University of Pittsburgh IMTRP program receive strong didactic training focusing on the most important themes requisite in the understanding of the pathogenesis and effective control and management of SMA.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Training Grants (D43)
Project #
3D43TW005884-03S1
Application #
6952189
Study Section
Special Emphasis Panel (ZAI1)
Program Officer
Sina, Barbara J
Project Start
2002-04-22
Project End
2006-02-28
Budget Start
2004-03-01
Budget End
2005-02-28
Support Year
3
Fiscal Year
2004
Total Cost
$14,383
Indirect Cost
Name
University of Pittsburgh
Department
Internal Medicine/Medicine
Type
Schools of Public Health
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Kumar, Prashant; Achieng, Angela O; Rajendran, Vinoth et al. (2017) Synergistic blending of high-valued heterocycles inhibits growth of Plasmodium falciparum in culture and P. berghei infection in mouse model. Sci Rep 7:6724
Raballah, Evans; Kempaiah, Prakasha; Karim, Zachary et al. (2017) CD4 T-cell expression of IFN-? and IL-17 in pediatric malarial anemia. PLoS One 12:e0175864
Munde, Elly O; Raballah, Evans; Okeyo, Winnie A et al. (2017) Haplotype of non-synonymous mutations within IL-23R is associated with susceptibility to severe malaria anemia in a P. falciparum holoendemic transmission area of Kenya. BMC Infect Dis 17:291
Munde, Elly O; Okeyo, Winnie A; Raballah, Evans et al. (2017) Association between Fc? receptor IIA, IIIA and IIIB genetic polymorphisms and susceptibility to severe malaria anemia in children in western Kenya. BMC Infect Dis 17:289
Davenport, Gregory C; Hittner, James B; Otieno, Vincent et al. (2016) Reduced Parasite Burden in Children with Falciparum Malaria and Bacteremia Coinfections: Role of Mediators of Inflammation. Mediators Inflamm 2016:4286576
Lalremruata, Albert; Magris, Magda; Vivas-Martínez, Sarai et al. (2015) Natural infection of Plasmodium brasilianum in humans: Man and monkey share quartan malaria parasites in the Venezuelan Amazon. EBioMedicine 2:1186-92
Ogutu, Bernhards R; Onyango, Kevin O; Koskei, Nelly et al. (2014) Efficacy and safety of artemether-lumefantrine and dihydroartemisinin-piperaquine in the treatment of uncomplicated Plasmodium falciparum malaria in Kenyan children aged less than five years: results of an open-label, randomized, single-centre study. Malar J 13:33
Were, Tom; Wesongah, Jesca O; Munde, Elly et al. (2014) Clinical chemistry profiles in injection heroin users from Coastal Region, Kenya. BMC Clin Pathol 14:32
Kempaiah, Prakasha; Davidson, Lisa B; Perkins, Douglas J et al. (2013) Cystic fibrosis CFBE41o- cells contain TLR1 SNP I602S and fail to respond to Mycobacterium abscessus. J Cyst Fibros 12:773-9
Rivas, Ariel L; Jankowski, Mark D; Piccinini, Renata et al. (2013) Feedback-based, system-level properties of vertebrate-microbial interactions. PLoS One 8:e53984

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