This application to renew our Global Infectious Disease Research Training (GIDRT) program at the University of Virginia will build upon our many lessons learned and track record working over many cycles of International Training and Research in Emerging Infectious Diseases (ITREID), Actions for Building Capacity (ABC) and GIDRT Fogarty support that has so greatly strengthened our research and training collaboration with the Federal University of Cear (UFC) in Fortaleza, Brazil. This experience is the strong foundation for strengthening our collaboration with the University of Venda (UNIVEN), a model, innovative, former homeland university in Limpopo Province in the northeast of South Africa, near the borders with Zimbabwe and Mozambique. UNIVEN is clearly poised to become a world-class research, teaching and service university, much like UFC was in northeast Brazil 20 years ago. Furthermore, UNIVEN attracts graduate students from other southern African countries such as Botswana, Lesotho, Malawi, Swaziland, Zambia, and Zimbabwe. Like South Africa, these countries are also experiencing acute shortages of trained individuals to help seek solutions to their particular human development problems. We believe our experience and lessons learned in Brazil have begun to take root at UNIVEN. We also believe that the transfer of our GIDRT program from Brazil to South Africa provides an opportunity to firmly establish infectious disease training at a site with limited training opportunities, a large burden of diseas, and a small, but growing research infrastructure. At UNIVEN, we have, in close collaboration with Dr. Pascal Bessong, formerly a Fogarty-supported trainee who is now Chair of Microbiology at UNIVEN, developed a cutting edge research program as well as research infrastructure. We have achieved this in part through our collaborative major Malnutrition and Enteric Disease Network (MAL-ED) study. This project, funded by an award from the Bill and Melinda Gates Foundation to the Foundation for the National Institutes of Health (FNIH), has supported Dr. Bessong, as he has led the establishment of a major new site for study of diarrheal illnesses and their long-term consequences. Given this success, we are now poised to take intervention science - applying our best science to testing novel approaches to disease control and improving health - to a whole new level by linking the laboratory bench to the bedside to the community and, importantly in our model, to come back from the community to the bench to elucidate novel interventions.

Public Health Relevance

The interactive, multidisciplinary and growing institutional linkages between the University of Virginia (UVA) and the University of Venda (UNIVEN) include a track record of successful training in microbiology, the Water and Health in Limpopo research project and the Malnutrition and Enteric Diseases Network (MAL-ED). This critical mass of research relevant to public health in South Africa, and the surrounding region, can be potentiated by GIDRT support to address relevant health concerns, advance the development of human capital, and build sustainable institutional capacity.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Training Grants (D43)
Project #
5D43TW006578-13
Application #
9023607
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Sina, Barbara J
Project Start
2003-09-05
Project End
2018-12-31
Budget Start
2016-01-01
Budget End
2016-12-31
Support Year
13
Fiscal Year
2016
Total Cost
Indirect Cost
Name
University of Virginia
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
065391526
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
Etta, Elizabeth M; Alayande, Doyinmola P; Mavhandu-Ramarumo, Lufuno G et al. (2018) HHV-8 Seroprevalence and Genotype Distribution in Africa, 1998?2017: A Systematic Review. Viruses 10:
Bolick, D T; Medeiros, P H Q S; Ledwaba, S E et al. (2018) The Critical Role of Zinc in a New Murine Model of Enterotoxigenic E. coli (ETEC) Diarrhea. Infect Immun :
Ngobeni, Renay; Samie, Amidou (2017) PREVALENCE OF TOXOPLASMA GONDII IGG AND IGM AND ASSOCIATED RISK FACTORS AMONG HIV-POSITIVE AND HIV-NEGATIVE PATIENTS IN VHEMBE DISTRICT OF SOUTH AFRICA. Afr J Infect Dis 11:1-9
Lima, Aldo A M; Leite, Álvaro M; Di Moura, Alessandra et al. (2017) Determinant Variables, Enteric Pathogen Burden, Gut Function and Immune-related Inflammatory Biomarkers Associated With Childhood Malnutrition: A Prospective Case-Control Study in Northeastern Brazil. Pediatr Infect Dis J 36:1177-1185
Ngobeni, Renay; Abhyankar, Mayuresh M; Jiang, Nona M et al. (2017) Entamoeba histolytica-Encoded Homolog of Macrophage Migration Inhibitory Factor Contributes to Mucosal Inflammation during Amebic Colitis. J Infect Dis 215:1294-1302
Modipane, Mahlatse B; Waldman, Ava Lena; Ritterband, Lee et al. (2016) Technology Use Among Patients in a Nonurban Southern U.S. HIV Clinic in 2015. Telemed J E Health 22:965-968
Bolick, David T; Kolling, Glynis L; Moore 2nd, John H et al. (2014) Zinc deficiency alters host response and pathogen virulence in a mouse model of enteroaggregative Escherichia coli-induced diarrhea. Gut Microbes 5:618-27
Azevedo, Orleâncio G R; Bolick, David T; Roche, James K et al. (2014) Apolipoprotein E plays a key role against cryptosporidial infection in transgenic undernourished mice. PLoS One 9:e89562
Bolick, David T; Chen, Tufeng; Alves, Luís Antonio O et al. (2014) Intestinal cell kinase is a novel participant in intestinal cell signaling responses to protein malnutrition. PLoS One 9:e106902
Medeiros, Pedro; Bolick, David T; Roche, James K et al. (2013) The micronutrient zinc inhibits EAEC strain 042 adherence, biofilm formation, virulence gene expression, and epithelial cytokine responses benefiting the infected host. Virulence 4:624-33

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