Abstract

This is a proposal to support a sabbatical leave for Dr. Philip Youderian in the laboratory of Dr. Guido Mora located at the Pontificia Universidad Catolica in Santiago, Chile. During this sabbatical leave, the P. I. intends to gain expertise in the study of the interaction of Salmonella typhi with epithelial cell lines. Salmonella continues to be a worldwide health problem and, therefore, understanding the mechanisms by which these microorganisms cause disease is of great importance. During the sabbatical leave, the P. I. intends to apply a combination of functional genomics and bacterial genetics techniques to identify genes that are essential for growth under condition that mimic those encounter during water-borne transmission as well as genes required for growth within epithelial cells.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
Unknown (F06)
Project #
1F06TW005645-01
Application #
6369178
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Program Officer
Michels, Kathleen M
Project Start
2001-09-06
Project End
Budget Start
2001-03-06
Budget End
Support Year
1
Fiscal Year
2001
Total Cost
$35,010
Indirect Cost

  Institution

Name
Texas A&M University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
047006379
City
College Station
State
TX
Country
United States
Zip Code
77845

  Publications

Fuentes, Derie E; Navarro, Claudio A; Tantalean, Juan C et al. (2005) The product of the qacC gene of Staphylococcus epidermidis CH mediates resistance to beta-lactam antibiotics in gram-positive and gram-negative bacteria. Res Microbiol 156:472-7
Hidalgo, Alejandro A; Trombert, A Nicole; Castro-Alonso, J C et al. (2004) Insertions of mini-Tn10 transposon T-POP in Salmonella enterica sv. typhi. Genetics 167:1069-77
Bueno, Susan M; Santiviago, Carlos A; Murillo, Alejandro A et al. (2004) Precise excision of the large pathogenicity island, SPI7, in Salmonella enterica serovar Typhi. J Bacteriol 186:3202-13
Santiviago, Carlos A; Toro, Cecilia S; Hidalgo, Alejandro A et al. (2003) Global regulation of the Salmonella enterica serovar typhimurium major porin, OmpD. J Bacteriol 185:5901-5
Santiviago, Carlos A; Fuentes, Juan A; Bueno, Susan M et al. (2002) The Salmonella enterica sv. Typhimurium smvA, yddG and ompD (porin) genes are required for the efficient efflux of methyl viologen. Mol Microbiol 46:687-98