Abstract

The nature and extent of number processing (NP) abilities in HIV is unclear. To date there have been no systematic studies examining NP in this population. The goal of the present study is to provide a comprehensive picture of NP abilities in people living with HIV. The general hypothesis is that patients with HIV will show deficits in NP abilities because of the known effects of HIV on the basal ganglia and the dorsolateral prefrontal cortex (DLPFC) circuit that includes the posterior parietal lobes. The same neural circuitry is involved in a second cognitive domain - visuospatial processing. This study will compare the nature of NP and visuospatial dysfunction in HIV. Participants with HIV and control adults will be examined on NP (number reasoning, number transcoding, number bisection, spatial number orientation, and arithmetic facts retrieval) and visuospatial abilities (spatial reasoning, spatial exploration, visuospatial problem solving, and constructional praxis) measured by standardized neuropsychological tests and by tests derived from the cognitive neuroscience literature. This comparison will shed light on the nature of NP in this neurodegenerative condition and will determine whether selective visuo-spatial deficits have impact on number processing domain. This distinction will guide further research leading to interventions to improve daily function in these cognitive domains in HIV. ? ? ?

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
1F31NS052131-01A2
Application #
7168275
Study Section
Special Emphasis Panel (ZRG1-AARR-G (02))
Program Officer
Wong, May
Project Start
2006-07-01
Project End
2007-09-30
Budget Start
2006-07-01
Budget End
2007-09-30
Support Year
1
Fiscal Year
2006
Total Cost
$5,193
Indirect Cost

  Institution

Name
Boston University
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
049435266
City
Boston
State
MA
Country
United States
Zip Code
02215

  Publications

Bogdanova, Yelena; Cronin-Golomb, Alice (2013) Alexithymia and apathy in Parkinson's disease: neurocognitive correlates. Behav Neurol 27:535-45
Stavitsky, Karina; Neargarder, Sandy; Bogdanova, Yelena et al. (2012) The impact of sleep quality on cognitive functioning in Parkinson's disease. J Int Neuropsychol Soc 18:108-17
Bogdanova, Yelena; Cronin-Golomb, Alice (2012) Neurocognitive correlates of apathy and anxiety in Parkinson's disease. Parkinsons Dis 2012:793076
Bogdanova, Yelena; Díaz-Santos, Mirella; Cronin-Golomb, Alice (2010) Neurocognitive correlates of alexithymia in asymptomatic individuals with HIV. Neuropsychologia 48:1295-304
Bogdanova, Yelena; Neargarder, Sandy; Cronin-Golomb, Alice (2008) Mapping mental number line in physical space: vertical and horizontal visual number line orientation in asymptomatic individuals with HIV. Neuropsychologia 46:2914-23