Obstructive sleep apnea (OSA) is a common problem, and cognitive deficits associated with OSA have been documented in many studies. While evidence suggests that cognitive dysfunction in OSA may be related to hypoxemia-induced damage to the frontal lobes and/or sub cortical areas, such a connection has not been directly established. Rather, it has been inferred from the finding that these deficits do not improve following treatment with continuous positive airway pressure (CPAP). The proposed study will attempt to directly connect both general and specific executive function deficits in OSA to the effects of intermittent nocturnal hypoxemia by comparing OSA subjects who differ in the severity of apnea-hypopnea associated hypoxemia, but who have been matched on other important indicators of disease severity (i.e., AHI, arousal index) on a number of neuropsychological measures of executive function. Establishing a direct connection between intermittent nocturnal hypoxemia and permanent cognitive deficits in OSA will emphasize the importance of early detection and treatment. Additionally, further clarifying the specific executive function deficits associated with OSA will allow for the development of cognitive rehabilitation strategies to assist these patients in better compensating for their cognitive difficulties.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
1F32HL071336-01A1
Application #
6693658
Study Section
Special Emphasis Panel (ZRG1-RPHB-2 (01))
Program Officer
Rothgeb, Ann E
Project Start
2003-09-26
Project End
2004-09-25
Budget Start
2003-09-26
Budget End
2004-09-25
Support Year
1
Fiscal Year
2003
Total Cost
$46,420
Indirect Cost
Name
National Jewish Health
Department
Type
DUNS #
076443019
City
Denver
State
CO
Country
United States
Zip Code
80206
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