Abstract

The overall aim of our studies is to determine the cellular and molecular mechanisms that lead to keloid growth. Establish primary fibroblast cultures from keloid and non-keloid tissues. Investigate mechanisms of the amino acid transport to proline as a precursor of increased collagen synthesis in keloids. To determine if specific growth factors (TGF-"""""""", TNF-"""""""", """"""""FGF, BFGF, PDGF and EGF) and cytokines will influence keloid growth, by regulating amino acid transport, & expression of matrix proteins such as collagen(s)and fibronectin. To investigate the role of the tumor suppressor genes p53, RB, CDD in keloids. And establish HLA typing in combination with PRC technology for keloid samples. To accomplish these goals we are using keloid tissue from patients who seek our services for removal of cosmetically unacceptable and/or symptomatic keloidsl

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Centers in Minority Institutions Award (G12)
Project #
5G12RR003026-13
Application #
6121446
Study Section
Project Start
1999-06-01
Project End
2000-09-29
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
13
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Charles R. Drew University of Medicine & Science
Department
Type
DUNS #
785877408
City
Los Angeles
State
CA
Country
United States
Zip Code
90059

  Publications

Martin, Karmarcha; Nashar, Toufic O (2013) E. coli Heat-labile Enterotoxin B Subunit as a Platform for the Delivery of HIV Gag p24 Antigen. J Clin Cell Immunol 4:
George, Sheba; Hamilton, Alison; Baker, Richard S (2012) How Do Low-Income Urban African Americans and Latinos Feel about Telemedicine? A Diffusion of Innovation Analysis. Int J Telemed Appl 2012:715194
Mangubat, Michael; Lutfy, Kabirullah; Lee, Martin L et al. (2012) Effect of nicotine on body composition in mice. J Endocrinol 212:317-26
Releford, Bill J; Frencher Jr, Stanley K; Yancey, Antronette K (2010) Health promotion in barbershops: balancing outreach and research in African American communities. Ethn Dis 20:185-8
Calderón, José Luis; Bazargan, Mohsen; Sangasubana, Nisaratana et al. (2010) A comparison of two educational methods on immigrant Latinas breast cancer knowledge and screening behaviors. J Health Care Poor Underserved 21:76-90
Releford, Bill J; Frencher Jr, Stanley K; Yancey, Antronette K et al. (2010) Cardiovascular disease control through barbershops: design of a nationwide outreach program. J Natl Med Assoc 102:336-45
Gonzalez-Cadavid, Nestor F; Rajfer, Jacob (2010) Treatment of Peyronie's disease with PDE5 inhibitors: an antifibrotic strategy. Nat Rev Urol 7:215-21
Pervin, Shehla; Chaudhuri, Gautam; Singh, Rajan (2010) NO to breast: when, why and why not? Curr Pharm Des 16:451-62
Anghel, A; Jamieson, C A M; Ren, X et al. (2010) Gene expression profiling following short-term and long-term morphine exposure in mice uncovers genes involved in food intake. Neuroscience 167:554-66
Vuong, Cassidy; Van Uum, Stan H M; O'Dell, Laura E et al. (2010) The effects of opioids and opioid analogs on animal and human endocrine systems. Endocr Rev 31:98-132

Showing the most recent 10 out of 234 publications