Abstract

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our long-term objectives of this proposal are to study the role of Elk-1 in growth and tumorigenicity of human prostate cancer cells. We have proposed the following specific aims: 1) Studies focused on testing the role of Elk-1 in suppressing the tumorigenicity of human prostate cancer cells. a. Develop stable PC-3 cell lines expressing Elk-1 proteins. b. Study expression of Elk-1, p21 and growth rate of PC-3 Elk-1 transfectants. c. Study invitro growth in soft agar. d. Study in vivo tumorigenicity in nude mice. 2) Studies directed towards testing the role of Elk-1 in the regulation of p21WAF1/CIP1 in human prostate cancer cell

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Centers in Minority Institutions Award (G12)
Project #
5G12RR003034-24
Application #
7959157
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2009-06-01
Project End
2010-05-31
Budget Start
2009-06-01
Budget End
2010-05-31
Support Year
24
Fiscal Year
2009
Total Cost
$94,129
Indirect Cost

  Institution

Name
Morehouse School of Medicine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
102005451
City
Atlanta
State
GA
Country
United States
Zip Code
30310

  Publications

Piano, Ilaria; Baba, Kenkichi; Claudia Gargini et al. (2018) Heteromeric MT1/MT2 melatonin receptors modulate the scotopic electroretinogram via PKC? in mice. Exp Eye Res 177:50-54
Owino, Sharon; Sánchez-Bretaño, Aida; Tchio, Cynthia et al. (2018) Nocturnal activation of melatonin receptor type 1 signaling modulates diurnal insulin sensitivity via regulation of PI3K activity. J Pineal Res 64:
Augello, Catherine J; Noll, Jessica M; Distel, Timothy J et al. (2018) Identification of novel blood biomarker panels to detect ischemic stroke in patients and their responsiveness to therapeutic intervention. Brain Res 1698:161-169
Greene, Sarah J (2018) The use and effectiveness of interactive progressive drawing in anatomy education. Anat Sci Educ 11:445-460
Chowdhury, Indrajit; Banerjee, Saswati; Driss, Adel et al. (2018) Curcumin attenuates proangiogenic and proinflammatory factors in human eutopic endometrial stromal cells through the NF-?B signaling pathway. J Cell Physiol :
Chowdhury, Indrajit; Branch, Alicia; Mehrabi, Sharifeh et al. (2017) Gonadotropin-Dependent Neuregulin-1 Signaling Regulates Female Rat Ovarian Granulosa Cell Survival. Endocrinology 158:3647-3660
Chen, Xiaoming; Cobbs, Alyssa; George, Jasmine et al. (2017) Endocytosis of Albumin Induces Matrix Metalloproteinase-9 by Activating the ERK Signaling Pathway in Renal Tubule Epithelial Cells. Int J Mol Sci 18:
Tchio Mantho, Cynthia I; Harbuzariu, Adriana; Gonzalez-Perez, Ruben R (2017) Histone deacetylases, microRNA and leptin crosstalk in pancreatic cancer. World J Clin Oncol 8:178-189
Harmon, Tia; Harbuzariu, Adriana; Lanier, Viola et al. (2017) Nanoparticle-linked antagonist for leptin signaling inhibition in breast cancer. World J Clin Oncol 8:54-66
Parker, Trisha C; Mohammed, Anaam; Leong, Traci et al. (2017) Rotavirus vaccination rate disparities seen among infants with acute gastroenteritis in Georgia. Ethn Health 22:585-595

Showing the most recent 10 out of 291 publications