Abstract

The specific aim of this project is to study the details of the solution structure and electronic charge distribution of K13Ln(W11O39si)2 and K17Ln(P2W17O61)2 families of compounds using spectroscopic and computational techniques as well as X-ray crystallography. 1. Investigate the binding and detailed molecular interactions of the oxoanions with the gp-120 glycoprotein, or peptide sequences, representative of regions of the gp- 120 glycoprotein, using fluorescence techniques and NMR spectroscopy. We will correlate the binding of the oxoanions and the protein with the anti-HIV results obtained from our preliminary studies. 2. Using information derived above, design and prepare new families of polyoxoanions, which should provide more precise interactions with the gp- 120 glycoprotein.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Centers in Minority Institutions Award (G12)
Project #
5G12RR003037-12
Application #
5224396
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

Luine, Victoria; Serrano, Peter; Frankfurt, Maya (2018) Rapid effects on memory consolidation and spine morphology by estradiol in female and male rodents. Horm Behav :
Avila, Jorge A; Alliger, Amber A; Carvajal, Brigett et al. (2017) Estradiol rapidly increases GluA2-mushroom spines and decreases GluA2-filopodia spines in hippocampus CA1. Hippocampus 27:1224-1229
Gupta, Rupal; Huang, Wenlin; Francesconi, Lynn C et al. (2017) Effect of positional isomerism and vanadium substitution on 51V magic angle spinning NMR Spectra Of Wells-Dawson polyoxotungstates. Solid State Nucl Magn Reson 84:28-33
Kiprowska, Magdalena J; Stepanova, Anna; Todaro, Dustin R et al. (2017) Neurotoxic mechanisms by which the USP14 inhibitor IU1 depletes ubiquitinated proteins and Tau in rat cerebral cortical neurons: Relevance to Alzheimer's disease. Biochim Biophys Acta Mol Basis Dis 1863:1157-1170
Urbanski, Mateusz M; Kingsbury, Lyle; Moussouros, Daniel et al. (2016) Myelinating glia differentiation is regulated by extracellular matrix elasticity. Sci Rep 6:33751
Oliver, Chicora F; Kabitzke, Patricia; Serrano, Peter et al. (2016) Repeated recall and PKM? maintain fear memories in juvenile rats. Learn Mem 23:710-713
He, Huifang; Deng, Kangwen; Siddiq, Mustafa M et al. (2016) Cyclic AMP and Polyamines Overcome Inhibition by Myelin-Associated Glycoprotein through eIF5A-Mediated Increases in p35 Expression and Activation of Cdk5. J Neurosci 36:3079-91
Carbone, Lorenzo; Verrelli, Roberta; Gobet, Mallory et al. (2016) Insight on the Li2S electrochemical process in a composite configuration electrode. New J Chem 40:2935-2943
Iñiguez, Sergio D; Aubry, Antonio; Riggs, Lace M et al. (2016) Social defeat stress induces depression-like behavior and alters spine morphology in the hippocampus of adolescent male C57BL/6 mice. Neurobiol Stress 5:54-64
Babkirk, Sarah; Luehring-Jones, Peter; Dennis-Tiwary, Tracy A (2016) Computer-mediated communication preferences predict biobehavioral measures of social-emotional functioning. Soc Neurosci 11:637-51

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