Abstract

This proposal outlines approaches to assessment of bleomycin- and H2O2-mediated oxidative cell wall damage in Aspergillus fumigatus and Cryptococcus neoformans, both AIDS pathogens.
The specific aims of this proposal are to identify cell wall targets of bleomycin in Saccharomyces cerevisiae. To this end, we will assay cell wall integrity and bleomycin susceptibility of bleomycin sensitive strains (blm mutants), cell wall mutants of known provenance and effect.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Centers in Minority Institutions Award (G12)
Project #
5G12RR003037-12
Application #
5224398
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

Luine, Victoria; Serrano, Peter; Frankfurt, Maya (2018) Rapid effects on memory consolidation and spine morphology by estradiol in female and male rodents. Horm Behav :
Avila, Jorge A; Alliger, Amber A; Carvajal, Brigett et al. (2017) Estradiol rapidly increases GluA2-mushroom spines and decreases GluA2-filopodia spines in hippocampus CA1. Hippocampus 27:1224-1229
Gupta, Rupal; Huang, Wenlin; Francesconi, Lynn C et al. (2017) Effect of positional isomerism and vanadium substitution on 51V magic angle spinning NMR Spectra Of Wells-Dawson polyoxotungstates. Solid State Nucl Magn Reson 84:28-33
Kiprowska, Magdalena J; Stepanova, Anna; Todaro, Dustin R et al. (2017) Neurotoxic mechanisms by which the USP14 inhibitor IU1 depletes ubiquitinated proteins and Tau in rat cerebral cortical neurons: Relevance to Alzheimer's disease. Biochim Biophys Acta Mol Basis Dis 1863:1157-1170
Carbone, Lorenzo; Verrelli, Roberta; Gobet, Mallory et al. (2016) Insight on the Li2S electrochemical process in a composite configuration electrode. New J Chem 40:2935-2943
Iñiguez, Sergio D; Aubry, Antonio; Riggs, Lace M et al. (2016) Social defeat stress induces depression-like behavior and alters spine morphology in the hippocampus of adolescent male C57BL/6 mice. Neurobiol Stress 5:54-64
Babkirk, Sarah; Luehring-Jones, Peter; Dennis-Tiwary, Tracy A (2016) Computer-mediated communication preferences predict biobehavioral measures of social-emotional functioning. Soc Neurosci 11:637-51
Yoon, Seungyeon A; Weierich, Mariann R (2016) Salivary biomarkers of neural hypervigilance in trauma-exposed women. Psychoneuroendocrinology 63:17-25
Jacome, Luis F; Barateli, Ketti; Buitrago, Dina et al. (2016) Gonadal Hormones Rapidly Enhance Spatial Memory and Increase Hippocampal Spine Density in Male Rats. Endocrinology 157:1357-62
Urbanski, Mateusz M; Kingsbury, Lyle; Moussouros, Daniel et al. (2016) Myelinating glia differentiation is regulated by extracellular matrix elasticity. Sci Rep 6:33751

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