The purpose of this proposal is to develop an Institute for Research into Health Issues of the Disadvantaged. The major objectives of the proposal over the next five years are to: (1) rebuild the RCMI program and expand biomedical research capacity throughout the University over a five year period; (2) extend the research infrastructure to all biomedical and behavioral research units at the TSU; (3) increase the physical space, type and quality of facilities dedicated to biomedical and behavioral research; (4) hire new Ph.D. trained biomedical scientists; and (5) double the number of publications to 16 per year, double the number of NIH proposal submissions to 46 per year and double the number of proposals awarded. The planned new approach for the instituted will focus RCMI research into two categorical areas (Environmental Health and Toxicology and Selected Ethnic Diseases and Health Issues). The infrastructure (facilities, personnel, management and operations) will encompass the two research areas campus wide, maintaining communication among and interface between all of the researchers. TSU will embark on a Biomedical Research Recruitment (BRFR) effort. This initiative is designed to improve the research infrastructure by increasing the number and quality of biomedical and behavioral research faculty investigating health issues disproportionately affecting disadvantaged populations. The proposal is consistent with the institution's renewed interest and commitment to increase both the level of research activity and the number of faculty members engaged in biomedical and behavioral research. We will hire six (6) new faculty members over the next grant period-two each in the biological sciences, environmental health and toxicology, and the pharmaceutical sciences. Start-up funds will be provided to each new faculty member to initiate their research programs. We will establish a new Biomarkers and Environmental Toxicology core laboratory and continued the development and user community of the existing Molecular Biopharmacology and Tissue Culture Laboratory. The involvement of researchers over the total TSU campus is intended to expand on the interface among researchers whose interests may touch on the same areas and particularly focus on aspects of ethnic diseases and environmental health and toxicology It is also intended to significantly expand research collaborations, research productivity and the grant application and the funding base among current TSU faculty.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Centers in Minority Institutions Award (G12)
Project #
5G12RR003045-15
Application #
6529979
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Program Officer
Mcclure, Shelia A
Project Start
1986-09-30
Project End
2004-08-31
Budget Start
2002-09-01
Budget End
2003-08-31
Support Year
15
Fiscal Year
2002
Total Cost
$1,312,793
Indirect Cost
Name
Texas Southern University
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
City
Houston
State
TX
Country
United States
Zip Code
77004
Oloyo, Ahmed K; Sofola, Olusoga A; Yakubu, Momoh A (2016) Orchidectomy attenuates high-salt diet-induced increases in blood pressure, renovascular resistance, and hind limb vascular dysfunction: role of testosterone. Clin Exp Pharmacol Physiol 43:825-33
Oyagbemi, Ademola Adetokunbo; Omobowale, Temidayo Olutayo; Adedapo, Adeolu Alex et al. (2016) Kolaviron, Biflavonoid Complex from the Seed of Garcinia kola Attenuated Angiotensin II- and Lypopolysaccharide-induced Vascular Smooth Muscle Cell Proliferation and Nitric Oxide Production. Pharmacognosy Res 8:S50-5
Liang, Su; Bian, Xiaomei; Liang, Dong et al. (2016) Solution formulation development and efficacy of MJC13 in a preclinical model of castration-resistant prostate cancer. Pharm Dev Technol 21:121-6
Robinson, Keila; Mock, Charlotta; Liang, Dong (2015) Pre-formulation studies of resveratrol. Drug Dev Ind Pharm 41:1464-9
Wang, Yan; Ye, Yuanqing; Lin, Jie et al. (2015) Genetic variants in matrix metalloproteinase genes as disposition factors for ovarian cancer risk, survival, and clinical outcome. Mol Carcinog 54:430-9
Liang, Su; Sanchez-Espiridion, Beatriz; Xie, Huan et al. (2015) Determination of proline in human serum by a robust LC-MS/MS method: application to identification of human metabolites as candidate biomarkers for esophageal cancer early detection and risk stratification. Biomed Chromatogr 29:570-7
Jimenez, Angelica; Adisa, Afolabi; Woodham, Cara et al. (2014) Determination of polycyclic aromatic hydrocarbons in roasted coffee. J Environ Sci Health B 49:828-35
Bell, Edward C; John, Mathew; Hughes, Rodney J et al. (2014) Ultra-performance liquid chromatographic determination of tocopherols and retinol in human plasma. J Chromatogr Sci 52:1065-70
Meng, Qing H; Xu, Enping; Hildebrandt, Michelle A T et al. (2014) Genetic variants in the fibroblast growth factor pathway as potential markers of ovarian cancer risk, therapeutic response, and clinical outcome. Clin Chem 60:222-32
Liang, Su; Bian, Xiaomei; Sivils, Jeffrey et al. (2014) Quantification of a New Anti-Cancer Molecule MJC13 Using a Rapid, Sensitive, and Reliable Liquid Chromatography-Tandem Mass Spectrometry Method. Am J Mod Chromatogr 1:1-11

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