Tuskegee University presents a proposal to continue to develop and strengthen its RCMI supported Center for Biomedical Research (CBR). An infrastructure build upon biomedical, molecular and information technology holds a critical position in the University's plan to prepare for the challenges of the 21st century. The CBR proposal was developed after careful institutional self analysis, both at the level of the University (e.g. strategic planning, SACS accreditation) as well as in individual colleges (e.g. AVMA accreditation). The overarching but complementary goals are: 1) to continue to strengthen the biomedical research infrastructure; 2) to support and promote the implementation of the new PhD program in the molecular and biomedical sciences; 3) to promote mechanisms to institutionalize the RCMI program. The CBR concept builds on a vision of studying health related problems of minorities through the use of three modeling approaches. These are: a) computer modeling, b) animal models, and c) in vitro models and systems. These modeling approaches are interrelated and provide powerful avenues to replace, supplement of minimize the use of animals and human subjects for research. At a time when the public has an intense sensitivity about the use of animals (and human subjects) for experimentation, the proposed modeling methods provide compelling and powerful alternatives that will have a lasting value in advancing biomedical research. The proposal has an Administrative and Core Research Laboratory Services component. In the second section the three modeling approaches are presented. TU's long term plan focuses on actively expanding its research in the areas of molecular biology, immunology, public health, epidemiology, reproductive and environmental biology, animal and computer modeling. By using the alternative modeling systems, TU scientists will be in a position to create an environment for a strategically productive and lasting biomedical research enterprise.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Centers in Minority Institutions Award (G12)
Project #
3G12RR003059-14S2
Application #
6592073
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Program Officer
Mcclure, Shelia A
Project Start
1988-06-01
Project End
2003-05-31
Budget Start
2001-06-01
Budget End
2002-05-31
Support Year
14
Fiscal Year
2002
Total Cost
$37,332
Indirect Cost
Name
Tuskegee University
Department
Type
Organized Research Units
DUNS #
128214178
City
Tuskegee
State
AL
Country
United States
Zip Code
36088
Mukherjee, Angana; Hollern, Daniel P; Williams, Oluwasina G et al. (2018) A Review of FOXI3 Regulation of Development and Possible Roles in Cancer Progression and Metastasis. Front Cell Dev Biol 6:69
Yates, Clayton; Long, Mark D; Campbell, Moray J et al. (2017) miRNAs as drivers of TMPRSS2-ERG negative prostate tumors in African American men. Front Biosci (Landmark Ed) 22:212-229
Chowdhury, Rupak; David, Nganwa; Bogale, Asseged et al. (2016) Assessing the Key Attributes of Low Utilization of Mammography Screening and Breast-self Exam among African-American Women. J Cancer 7:532-7
Jones, Jacqueline; Mukherjee, Angana; Karanam, Balasubramanyam et al. (2016) African Americans with pancreatic ductal adenocarcinoma exhibit gender differences in Kaiso expression. Cancer Lett 380:513-22
Wang, Honghe; Liu, Wei; Black, ShaNekkia et al. (2016) Kaiso, a transcriptional repressor, promotes cell migration and invasion of prostate cancer cells through regulation of miR-31 expression. Oncotarget 7:5677-89
Reams, R Renee; Jones-Triche, Jacqueline; Chan, Owen T M et al. (2015) Immunohistological analysis of ABCD3 expression in Caucasian and African American prostate tumors. Biomed Res Int 2015:132981
Arora, Ritu; Schmitt, David; Karanam, Balasubramanyam et al. (2015) Inhibition of the Warburg effect with a natural compound reveals a novel measurement for determining the metastatic potential of breast cancers. Oncotarget 6:662-78
Jones, Jacqueline; Wang, Honghe; Karanam, Balasubramanyam et al. (2014) Nuclear localization of Kaiso promotes the poorly differentiated phenotype and EMT in infiltrating ductal carcinomas. Clin Exp Metastasis 31:497-510
Okumu, Lilian A; Braden, Tim D; Vail, Krystal et al. (2014) Low androgen induced penile maldevelopment involves altered gene expression of biomarkers of smooth muscle differentiation and a key enzyme regulating cavernous smooth muscle cell tone. J Urol 192:267-73
Theodore, Shaniece C; Davis, Melissa; Zhao, Fu et al. (2014) MicroRNA profiling of novel African American and Caucasian Prostate Cancer cell lines reveals a reciprocal regulatory relationship of miR-152 and DNA methyltranferase 1. Oncotarget 5:3512-25

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