Abstract

One member of Area II is using molecular techniques to study evolution. Dr. Gail Simmons and her students have expanded their study of hobo transposable elements into several other species in the genus Drosophila. Having found that hobo elements within the D. melanogaster species complex appear to have been horizontally (interspecifically) transferred, they have developed PCR primers that allow them to determine the degree of DNA sequence divergence between hobo elements from D. melanogaster and hobos from other species in the genus. The results indicate that a complex mixture of horizontal and vertical transmission has occurred. Current efforts are directed at discovering the exact pattern of transmission of hobo.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Centers in Minority Institutions Award (G12)
Project #
5G12RR003060-12
Application #
5224438
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

Das, Bidyut; Shi, Lingyan; Budansky, Yury et al. (2018) Alzheimer mouse brain tissue measured by time resolved fluorescence spectroscopy using single- and multi-photon excitation of label free native molecules. J Biophotonics 11:
Nicolas, Laura; Cols, Montserrat; Choi, Jee Eun et al. (2018) Generating and repairing genetically programmed DNA breaks during immunoglobulin class switch recombination. F1000Res 7:458
Juarez, Michelle T; Kenet, Chloe M (2018) Translating Research as an Approach to Enhance Science Engagement. Int J Environ Res Public Health 15:
Zheng, Simin; Kusnadi, Anthony; Choi, Jee Eun et al. (2018) NME proteins regulate class switch recombination. FEBS Lett :
Nicholl, Iain D; Matsui, Tsutomu; Weiss, Thomas M et al. (2018) ?-Catenin Structure and Nanoscale Dynamics in Solution and in Complex with F-Actin. Biophys J 115:642-654
Shi, Lingyan; Lu, Luyao; Harvey, George et al. (2017) Label-Free Fluorescence Spectroscopy for Detecting Key Biomolecules in Brain Tissue from a Mouse Model of Alzheimer's Disease. Sci Rep 7:2599
Huang, Wenlin; Serra, Olga; Dastmalchi, Keyvan et al. (2017) Comprehensive MS and Solid-State NMR Metabolomic Profiling Reveals Molecular Variations in Native Periderms from Four Solanum tuberosum Potato Cultivars. J Agric Food Chem 65:2258-2274
Callaway, David J E; Matsui, Tsutomu; Weiss, Thomas et al. (2017) Controllable Activation of Nanoscale Dynamics in a Disordered Protein Alters Binding Kinetics. J Mol Biol 429:987-998
Patel, Joy; Lama, Lodoe; Hoffmann, Niklas A et al. (2017) RNA polymerase III initiation on coligo DNA templates containing loops of variable sequence, size and nucleotide chemistry. Gene 612:49-54
Orlova, Natalia; Gerding, Matthew; Ivashkiv, Olha et al. (2017) The replication initiator of the cholera pathogen's second chromosome shows structural similarity to plasmid initiators. Nucleic Acids Res 45:3724-3737

Showing the most recent 10 out of 298 publications