The UHM Research Centers in Minority Institutions Program (RCMI) has continued to work towards its overall goal of catalyzing excellence in new initiatives in health-related research.. The focus of the current program is in four activities: Core Support, Molecular Endocrinology, Retrovirology and Native Hawaiian Health Research. Core Support -- is designed to maintain and extend the level of achievement of the cell, molecular and neuro-behavioral foci of the first five years by providing indirect, selective and cost- effective support for student research resources, electron microscopy and molecular biology facilities, shops, a computer specialist and a biostatistician to support all targeted activities. RCMI support has attracted significant State matching for these elements contributing to the competitive posture of our faculty. Molecular Endocrinology -- a new area of selective excellence, brings together human and physical resources in the Pacific Biomedical Research Center (PBRC) and the Medical School. The objective is to bring junior faculty up to the competitive level required for developing FIRST, R01 or P01 grant proposals, by providing mentoring, technical support, equipment and supplies for pilot research projects in endocrinology. Retrovirology -- draws on resources in PBRC, the Cancer Research Center of Hawaii (CRCH) and the Medical School and consolidates our efforts in basic, epidemiologic, and clinical studies of the human retroviruses, HIV and HTLV-1, into a single activity complementing a separately funded AIDS Clinical Trials Unit. Native Hawaiian Health Research -- a new initiative, brings together resources from PBRC, the Medical School and local community health groups in a collaborative pilot effort to study risks of cardiovascular disease and diabetes in native Hawaiians.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Centers in Minority Institutions Award (G12)
Project #
5G12RR003061-10
Application #
2281893
Study Section
Special Emphasis Panel (SRC)
Project Start
1986-09-30
Project End
1996-08-31
Budget Start
1995-09-22
Budget End
1996-08-31
Support Year
10
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Hawaii
Department
Type
Other Domestic Higher Education
DUNS #
121911077
City
Honolulu
State
HI
Country
United States
Zip Code
96822
Marciel, Michael P; Rose, Aaron H; Martinez, Verena et al. (2018) Calpain-2 inhibitor treatment preferentially reduces tumor progression for human colon cancer cells expressing highest levels of this enzyme. Cancer Med 7:175-183
Marciel, Michael P; Khadka, Vedbar S; Deng, Youpeng et al. (2018) Selenoprotein K deficiency inhibits melanoma by reducing calcium flux required for tumor growth and metastasis. Oncotarget 9:13407-13422
Priemer, David S; Wang, Mingsheng; Zhang, Shaobo et al. (2018) Small-cell Carcinomas of the Urinary Bladder and Prostate: TERT Promoter Mutation Status Differentiates Sites of Malignancy and Provides Evidence of Common Clonality Between Small-cell Carcinoma of the Urinary Bladder and Urothelial Carcinoma. Eur Urol Focus 4:880-888
Pomozi, Viola; Brampton, Christopher; Szeri, Flóra et al. (2017) Functional Rescue of ABCC6 Deficiency by 4-Phenylbutyrate Therapy Reduces Dystrophic Calcification in Abcc6-/- Mice. J Invest Dermatol 137:595-602
Norton, Robert L; Fredericks, Gregory J; Huang, Zhi et al. (2017) Selenoprotein K regulation of palmitoylation and calpain cleavage of ASAP2 is required for efficient Fc?R-mediated phagocytosis. J Leukoc Biol 101:439-448
Baumer, Yvonne; McCurdy, Sara; Weatherby, Tina M et al. (2017) Hyperlipidemia-induced cholesterol crystal production by endothelial cells promotes atherogenesis. Nat Commun 8:1129
Wilcox, Christie L; Headlam, Jasmine L; Doyle, Thomas K et al. (2017) Assessing the Efficacy of First-Aid Measures in Physalia sp. Envenomation, Using Solution- and Blood Agarose-Based Models. Toxins (Basel) 9:
Yanagihara, Angel Anne; Wilcox, Christie L (2017) Cubozoan Sting-Site Seawater Rinse, Scraping, and Ice Can Increase Venom Load: Upending Current First Aid Recommendations. Toxins (Basel) 9:
Chang, Linda; Løhaugen, Gro C; Andres, Tamara et al. (2017) Adaptive working memory training improved brain function in human immunodeficiency virus-seropositive patients. Ann Neurol 81:17-34
Doyle, Thomas K; Headlam, Jasmine L; Wilcox, Christie L et al. (2017) Evaluation of Cyanea capillata Sting Management Protocols Using Ex Vivo and In Vitro Envenomation Models. Toxins (Basel) 9:

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