This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The research support services sponsored by the RCMI program are the Molecular Biology Research Laboratory (MBRL), the Cell Culture Research Laboratory (CCRL) and the Scientific Imaging Center (SIC). We propose to add enhancements to an existing computer facility to make it capable of handling computational biology/bioinformatics calculations and data analysis.The RCMI support for these facilities will include (in addition to the equipment) 100% of the salary and fringe benefits for the RCMI Facilities Manager (for the MBRL, SIC, and CCRL), the MBRL Coordinator and Research Technician, and 20% of the salary for the manager of the computer facility. Other support will include a minimal supply allowance for each facility to purchase disposable supplies and gases, equipment purchases (as recommended by Center scientists), service contracts on equipment and an equipment repair allowance for service of instrumentation that is not under service contract.It is proposed that RCMI continue to support the three facilities highlighted above (MBRL, SIC and CCRL) for the next funding cycle. The facilities have contributed significantly to the enhancement of the biomedical research infrastructure at the University and to the research productivity of RCMI-affiliated scientists by providing equipment not available in an individual investigator's laboratory. These facilities have also provided training in state-of-the-art methodologies for scientists, staff and students. It is also proposed that RCMI support the enhancement of the computer facility to allow interested scientists to use it for computational biology/bioinformatics research.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Centers in Minority Institutions Award (G12)
Project #
2G12RR003062-22
Application #
7715355
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2008-09-01
Project End
2009-06-30
Budget Start
2008-09-01
Budget End
2009-06-30
Support Year
22
Fiscal Year
2008
Total Cost
$324,434
Indirect Cost
Name
Clark Atlanta University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
065325177
City
Atlanta
State
GA
Country
United States
Zip Code
30314
Morton, Derrick J; Patel, Divya; Joshi, Jugal et al. (2017) ID4 regulates transcriptional activity of wild type and mutant p53 via K373 acetylation. Oncotarget 8:2536-2549
Joshi, Jugal Bharat; Patel, Divya; Morton, Derrick J et al. (2017) Inactivation of ID4 promotes a CRPC phenotype with constitutive AR activation through FKBP52. Mol Oncol 11:337-357
Komaragiri, Shravan Kumar; Bostanthirige, Dhanushka H; Morton, Derrick J et al. (2016) ID4 promotes AR expression and blocks tumorigenicity of PC3 prostate cancer cells. Biochem Biophys Res Commun 478:60-66
Wilder, Catera L; Walton, Charlene; Watson, Valencia et al. (2016) Differential cathepsin responses to inhibitor-induced feedback: E-64 and cystatin C elevate active cathepsin S and suppress active cathepsin L in breast cancer cells. Int J Biochem Cell Biol 79:199-208
Burton, Liza J; Smith, Basil A; Smith, Bethany N et al. (2015) Muscadine grape skin extract can antagonize Snail-cathepsin L-mediated invasion, migration and osteoclastogenesis in prostate and breast cancer cells. Carcinogenesis 36:1019-27
Goodson 3rd, William H; Lowe, Leroy; Carpenter, David O et al. (2015) Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead. Carcinogenesis 36 Suppl 1:S254-96
Brown, Shanora G; Knowell, Ashley E; Hunt, Aisha et al. (2015) Interferon inducible antiviral MxA is inversely associated with prostate cancer and regulates cell cycle, invasion and Docetaxel induced apoptosis. Prostate 75:266-79
Muniyan, Sakthivel; Chou, Yu-Wei; Tsai, Te-Jung et al. (2015) p66Shc longevity protein regulates the proliferation of human ovarian cancer cells. Mol Carcinog 54:618-31
Chinaranagari, Swathi; Sharma, Pankaj; Bowen, Nathan J et al. (2015) Prostate cancer epigenome. Methods Mol Biol 1238:125-40
Mandal, S; Abebe, F; Chaudhary, J (2014) -174G/C polymorphism in the interleukin-6 promoter is differently associated with prostate cancer incidence depending on race. Genet Mol Res 13:139-51

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