Background: Veterans with serious mental illness (SMI) have high rates of homelessness and may require unique supports. Impairments in executive functions (EFs) such as emotion regulation, planning, and decision making are common in this population, interfere with negotiation of real-world problems leading to housing loss, and have been linked to negative behaviors which can result in homelessness. There is a need to intervene to improve EFs among homeless Veterans with SMI with the goal of increasing housing stability. Interventions exist but have not yet been adapted for or tested with homeless Veterans with SMI. Significance/Impact: VA has dedicated significant resources to homeless services, and considerable research efforts have been devoted to identifying factors linked to poor housing and community integration outcomes. Although there is abundant evidence that [decision making and related] EFs are impaired in individuals who are homeless, live with SMI, or both, and that this impacts a person's ability to attain and retain housing, interventions to improve EFs have not been adapted, tested, or implemented with homeless Veterans. This proposal addresses the HSR&D Major Priority Domains of Mental and Behavioral Health and Healthcare Equity and Health Disparities, and the High-Priority Research Topics of vulnerable populations, intersection of vulnerable populations, and impact of social determinants of health on outcomes of care. Innovation: The BrainWise program, which will be adapted and pilot tested in this study, is an effective critical thinking intervention which has demonstrated benefits in various populations of youth and adults including homeless men, but to our knowledge has not been administered to persons with SMI or to Veterans.
Specific Aims : (1.) Adapt an effective critical thinking group intervention (BrainWise) for use with homeless- experienced Veterans with serious mental illness, utilizing key stakeholder feedback; (2.) In a pilot trial with Veterans with serious mental illness enrolled in a Homeless Patient Aligned Care Team clinic, study the feasibility, acceptability, and fidelity of the adapted intervention; (3.) Assess the feasibility of proposed methods for measuring of executive functions, knowledge of BrainWise content, housing history, and substance use in the study sample, and obtain descriptive statistics to inform a subsequent larger study. Methodology: We will interview key stakeholders (clinicians and administrators from HPACT and HUD- VASH, and Veteran patients) about the BrainWise curriculum in order to inform the adaptation of the program's content and delivery. We will then deliver the adapted intervention to [two simultaneous groups] of 8?12 homeless Veteran participants with SMI over the course of 8?10 weekly group intervention sessions. Focus groups will be conducted immediately after each intervention session in order to solicit Veteran feedback about the intervention. A final focus group will be held after the last intervention session for both groups, to gather feedback about the intervention as a whole. Reflections from group facilitators will be collected after each session in order to inform further modifications. Participants in the intervention will complete measures of EFs, BrainWise knowledge, housing history, and substance use before and after intervention. Next Steps/Implementation: Results of this pilot will be used to inform a larger controlled hybrid trial to assess effectiveness and implementation of the adapted intervention for homeless Veterans with SMI.

Public Health Relevance

The intractable problem of Veteran homelessness calls for approaches aimed at subgroups who are at particularly high risk, such as Veterans with serious mental illness (SMI). Impaired executive functions (EFs) are common in persons who live with SMI, are homeless, or both. EFs are the set of abilities involved in planning [and decision making in the service of] goal attainment. [Decision making is] particularly relevant to housing stability since [the ability to make adaptive decisions] is needed to successfully negotiate real-world problems and challenges. There is a need to intervene to improve [decision making and other] EFs among homeless Veterans with SMI with the aim of improving housing stability. Interventions exist but have not been adapted for or tested with homeless Veterans with SMI. This study will adapt and pilot test an effective intervention for improving EFs (BrainWise) for use with homeless-experienced Veterans with SMI, and assess the feasibility, acceptability, and fidelity in order to inform a larger implementation and effectiveness trial.

Agency
National Institute of Health (NIH)
Institute
Veterans Affairs (VA)
Type
Veterans Administration (I21)
Project #
1I21HX002982-01A1
Application #
9950810
Study Section
HSR-4 Mental and Behavioral Health (HSR4)
Project Start
2020-09-01
Project End
2021-08-31
Budget Start
2020-09-01
Budget End
2021-08-31
Support Year
1
Fiscal Year
2020
Total Cost
Indirect Cost
Name
VA Greater Los Angeles Healthcare System
Department
Type
DUNS #
066689118
City
Los Angeles
State
CA
Country
United States
Zip Code
90073