Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Scientist Development Award - Research (K02)
Project #
5K02MH001231-08
Application #
6391320
Study Section
Special Emphasis Panel (ZRG1-MDCN-5 (01))
Program Officer
Brady, Linda S
Project Start
1994-08-01
Project End
2005-03-31
Budget Start
2001-04-01
Budget End
2002-03-31
Support Year
8
Fiscal Year
2001
Total Cost
$130,044
Indirect Cost

  Institution

Name
University of Tennessee Health Science Center
Department
Pharmacology
Type
Schools of Medicine
DUNS #
941884009
City
Memphis
State
TN
Country
United States
Zip Code
38163

  Publications

Cashman, John R; Voelker, Troy; Zhang, Han-Ting et al. (2009) Dual inhibitors of phosphodiesterase-4 and serotonin reuptake. J Med Chem 52:1530-9
Hajjhussein, Hassan; Suvarna, Neesha U; Gremillion, Carmen et al. (2007) Changes in NMDA receptor-induced cyclic nucleotide synthesis regulate the age-dependent increase in PDE4A expression in primary cortical cultures. Brain Res 1149:58-68
Zhang, Han-Ting; Zhao, Yu; Huang, Ying et al. (2004) Inhibition of the phosphodiesterase 4 (PDE4) enzyme reverses memory deficits produced by infusion of the MEK inhibitor U0126 into the CA1 subregion of the rat hippocampus. Neuropsychopharmacology 29:1432-9
Ye, Y; Jackson, K; Houslay, M D et al. (2001) Development of rolipram-sensitive, cyclic AMP phosphodiesterase (PDE4) in rat primary neuronal cultures. Brain Res Dev Brain Res 130:115-21
Crissman, A M; Makhay, M M; O'Donnell, J M (2001) Discriminative stimulus effects of centrally administered isoproterenol in rats: mediation by beta-1 adrenergic receptors. Psychopharmacology (Berl) 154:70-5
Zhang, H T; Crissman, A M; Dorairaj, N R et al. (2000) Inhibition of cyclic AMP phosphodiesterase (PDE4) reverses memory deficits associated with NMDA receptor antagonism. Neuropsychopharmacology 23:198-204
Zavecz, J H; Bueno, O; Maloney, R E et al. (2000) Cardiac excitation-contraction coupling in the portal hypertensive rat. Am J Physiol Gastrointest Liver Physiol 279:G28-39
O'Donnell, J M (1997) Pharmacological characterization of the discriminative stimulus effects of clenbuterol in rats. Pharmacol Biochem Behav 58:813-8
Ye, Y; Conti, M; Houslay, M D et al. (1997) Noradrenergic activity differentially regulates the expression of rolipram-sensitive, high-affinity cyclic AMP phosphodiesterase (PDE4) in rat brain. J Neurochem 69:2397-404
Ye, Y; O'Donnell, J M (1996) Diminished noradrenergic stimulation reduces the activity of rolipram-sensitive, high-affinity cyclic AMP phosphodiesterase in rat cerebral cortex. J Neurochem 66:1894-902

Showing the most recent 10 out of 15 publications