Research: Work will be conducted in several projects relating the mechanics and biology of bones. The primary project is the study of the remodeling response induced in bone by applied mechanical stresses. An ongoing series of animal studies will be completed in which controlled loads are applied to the rabbit tibia by external loading apparatus. The remodeling response versus imposed strain distribution is quantified. The second major effort is the study of properties of healing bone grafts. In two separate projects the mechanical and morphological properties of grafted bone as influenced by vascularity and immunological factors are being studied. Training: To participate in the regularly scheduled weekly conferences of the Department of Orthopaedics, including basic sciences conference, fracture conference and research conference; to participate as appropriate in the musculoskeletal aspects of the CWRU Phase II medical curriculum; to collaborate in the Functional Anatomy and Biomechanics courses of the Biomechanics curriculum.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases (NIADDK)
Type
Modified Research Career Development Award (K04)
Project #
5K04AM000812-05
Application #
3071082
Study Section
Applied Physiology Study Section (AFY)
Project Start
1981-09-01
Project End
1986-08-31
Budget Start
1985-09-01
Budget End
1986-08-31
Support Year
5
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Type
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Kotzar, G M; Davy, D T; Berilla, J et al. (1995) Torsional loads in the early postoperative period following total hip replacement. J Orthop Res 13:945-55
Bensusan, J S; Davy, D T; Goldberg, V M et al. (1992) The effects of vascularity and cyclosporin A on the mechanical properties of canine fibular autografts. J Biomech 25:415-20
Kotzar, G M; Davy, D T; Goldberg, V M et al. (1991) Telemeterized in vivo hip joint force data: a report on two patients after total hip surgery. J Orthop Res 9:621-33
Audu, M L; Davy, D T (1985) The influence of muscle model complexity in musculoskeletal motion modeling. J Biomech Eng 107:147-57