This is a request for a K05 Senior Scientist Research Career Award (RCA) as a competing continuation of #5 K05 DA00017.
The specific aims of the proposed five-year research program are the following: 1. Develop new psychometric methods for drug abuse research; 2. Apply these newly developed methods to important drug abuse data sets; 3. Generate practical improvements in methodology; 4. Create nontechnical papers and tutorials to improve methodology in drug abuse research; and 5. Advise drug abuse and health researchers and government agencies on methodology. The research program is directed towards the development of new multivariate psychometric and statistical techniques that hold special promise for improving the quality of psychosocial, social, behavioral, epidemiological, and functional imaging health-related research on drug use and abuse. Methods for robustly analyzing experimental and nonexperimental drug abuse data that may contain selectivity, outlier cases, arbitrary distributions, errors in measurement, nonstandard sampling plans, small samples, dependent observations, etc. will be developed. Special attention is given to structural equation models that may involve latent variables in mediation and moderator relations. Optimal small sample, missing data, robust, multilevel nonnormal, bootstrap, functional imaging, supercomputer research methods are a special focus. While no data will be gathered under this grant, the newly developed techniques will be extensively evaluated for their practical relevance to drug abuse research by addressing important substantive issues in drug abuse on high-quality data obtained in association with NIDA/UCLA program project grant P01 DA01070, via collaboration with brain mapping researchers and nationally active substance abuse researchers working on their own projects, as well as by cooperation with NIDA and other health-related agencies. Methods that are developed under this grant also will be widely disseminated.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Scientist Award (K05)
Project #
5K05DA000017-29
Application #
6800380
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Thomas, Yonette
Project Start
1976-08-01
Project End
2006-07-31
Budget Start
2004-08-01
Budget End
2005-07-31
Support Year
29
Fiscal Year
2004
Total Cost
$111,492
Indirect Cost
Name
University of California Los Angeles
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Pinzón, Natalia; Li, Blaise; Martinez, Laura et al. (2017) microRNA target prediction programs predict many false positives. Genome Res 27:234-245
Tsai, Jonathan M; Koh, Pang Wei; Stefanska, Ania et al. (2017) Localized hepatic lobular regeneration by central-vein-associated lineage-restricted progenitors. Proc Natl Acad Sci U S A 114:3654-3659
Hunt, Tyler D; Bentler, Peter M (2015) Quantile lower bounds to reliability based on locally optimal splits. Psychometrika 80:182-95
Moran, Yehu; Fredman, David; Praher, Daniela et al. (2014) Cnidarian microRNAs frequently regulate targets by cleavage. Genome Res 24:651-63
Bentler, Peter M; Huang, Wenjing (2014) On Components, Latent Variables, PLS and Simple Methods: Reactions to Rigdon's Rethinking of PLS. Long Range Plann 47:138-145
Tong, Xiaoxiao; Bentler, Peter M (2013) EVALUATION OF A NEW MEAN SCALED AND MOMENT ADJUSTED TEST STATISTIC FOR SEM. Struct Equ Modeling 20:148-156
Wu, Jianmin; Bentler, Peter M (2013) Limited Information Estimation in Binary Factor Analysis: A Review and Extension. Comput Stat Data Anal 57:392-403
An, Xinming; Yang, Qing; Bentler, Peter M (2013) A latent factor linear mixed model for high-dimensional longitudinal data analysis. Stat Med :
An, Xinming; Bentler, Peter M (2013) Nesting Monte Carlo EM for high-dimensional item factor analysis. J Stat Comput Simul 83:25-36
Lin, Johnny; Bentler, Peter M (2012) A Third Moment Adjusted Test Statistic for Small Sample Factor Analysis. Multivariate Behav Res 47:448-462

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