Abstract

The goal is to continue fundamental research into neurochemical mechanisms of psychoactive drugs. Areas that will be a focus of attention during the coming years include the following. Work on the phosphoinositide cycle will be emphasized. Molecular characterization of the IP3 receptor that mediates calcium release will be continued. Isolation of the IP4 receptor, its reconstitution and cloning will be explored. Nitric oxide will be evaluated as a messenger molecule in the action of neurotransmitters, especially excitatory amino acids. Molecular mechanisms of olfaction will be explored. An odorant binding protein which has been cloned and expressed win be evaluated for interactions with potential binding sites in nasal tissue. Alterations in cyclic nucleotide levels in response to odorants will be evaluated. Attempts will be made to isolate peripheral type benzodiazepine receptors and characterize them at a molecular level. Endothelin will be explored as a potential neurotransmitter.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Scientist Award (K05)
Project #
5K05DA000074-12
Application #
3075377
Study Section
Drug Abuse Biomedical Research Review Committee (DABR)
Project Start
1980-07-01
Project End
1995-06-30
Budget Start
1991-07-01
Budget End
1992-06-30
Support Year
12
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Yuan, Guoxiang; Vasavda, Chirag; Peng, Ying-Jie et al. (2015) Protein kinase G-regulated production of H2S governs oxygen sensing. Sci Signal 8:ra37
Peng, Ying-Jie; Makarenko, Vladislav V; Nanduri, Jayasri et al. (2014) Inherent variations in CO-H2S-mediated carotid body O2 sensing mediate hypertension and pulmonary edema. Proc Natl Acad Sci U S A 111:1174-9
Bang, Sookhee; Kim, Seyun; Dailey, Megan J et al. (2012) AMP-activated protein kinase is physiologically regulated by inositol polyphosphate multikinase. Proc Natl Acad Sci U S A 109:616-20
Dailey, Megan J; Kim, Seyun (2012) Inositol polyphosphate multikinase: an emerging player for the central action of AMP-activated protein kinase. Biochem Biophys Res Commun 421:1-3
Kim, Seyun; Kim, Sangwon F; Maag, David et al. (2011) Amino acid signaling to mTOR mediated by inositol polyphosphate multikinase. Cell Metab 13:215-21
Maag, David; Maxwell, Micah J; Hardesty, Douglas A et al. (2011) Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB. Proc Natl Acad Sci U S A 108:1391-6
Ho, Gary P H; Selvakumar, Balakrishnan; Mukai, Jun et al. (2011) S-nitrosylation and S-palmitoylation reciprocally regulate synaptic targeting of PSD-95. Neuron 71:131-41
Mustafa, Asif K; Sikka, Gautam; Gazi, Sadia K et al. (2011) Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channels. Circ Res 109:1259-68
Sen, Nilkantha; Snyder, Solomon H (2010) Protein modifications involved in neurotransmitter and gasotransmitter signaling. Trends Neurosci 33:493-502
Paul, B D; Snyder, S H (2010) The unusual amino acid L-ergothioneine is a physiologic cytoprotectant. Cell Death Differ 17:1134-40

Showing the most recent 10 out of 28 publications