Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Career Awards (K06)
Project #
5K06AI004739-43
Application #
6789401
Study Section
Special Emphasis Panel (NSS)
Program Officer
Park, Eun-Chung
Project Start
1977-09-01
Project End
2007-08-31
Budget Start
2004-09-01
Budget End
2005-08-31
Support Year
43
Fiscal Year
2004
Total Cost
$34,128
Indirect Cost
Name
Saint Louis University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
050220722
City
Saint Louis
State
MO
Country
United States
Zip Code
63103
Zhao, Ling-Jun; Loewenstein, Paul M; Green, Maurice (2017) Enhanced MYC association with the NuA4 histone acetyltransferase complex mediated by the adenovirus E1A N-terminal domain activates a subset of MYC target genes highly expressed in cancer cells. Genes Cancer 8:752-761
Zhao, Ling-Jun; Loewenstein, Paul M; Green, Maurice (2017) Adenovirus E1A TRRAP-targeting domain-mediated enhancement of MYC association with the NuA4 complex activates a panel of MYC target genes enriched for gene expression and ribosome biogenesis. Virology 512:172-179
Zhao, Ling-Jun; Loewenstein, Paul M; Green, Maurice (2016) Ad E1A 243R oncoprotein promotes association of proto-oncogene product MYC with the NuA4/Tip60 complex via the E1A N-terminal repression domain. Virology 499:178-184
Zhao, Ling-Jun; Loewenstein, Paul M; Green, Maurice (2016) The adenoviral E1A N-terminal domain represses MYC transcription in human cancer cells by targeting both p300 and TRRAP and inhibiting MYC promoter acetylation of H3K18 and H4K16. Genes Cancer 7:98-109
Loewenstein, Paul M; Wu, Shwu-Yuan; Chiang, Cheng-Ming et al. (2012) The adenovirus E1A N-terminal repression domain represses transcription from a chromatin template in vitro. Virology 428:70-5
Loewenstein, Paul M; Green, Maurice (2011) Expression of the Adenovirus Early Gene 1A Transcription-Repression Domain Alone Downregulates HER2 and Results in the Death of Human Breast Cancer Cells Upregulated for the HER2 Proto-Oncogene. Genes Cancer 2:737-44
Green, Maurice; Panesar, Ninder K; Loewenstein, Paul M (2008) Adenovirus E1A proteins are closely associated with chromatin in productively infected and transformed cells. Virology 371:1-7
Weeks, B S; Desai, K; Loewenstein, P M et al. (1993) Identification of a novel cell attachment domain in the HIV-1 Tat protein and its 90-kDa cell surface binding protein. J Biol Chem 268:5279-84
Kamine, J; Loewenstein, P; Green, M (1991) Mapping of HIV-1 Tat protein sequences required for binding to Tar RNA. Virology 182:570-7
Rawls, J A; Pusztai, R; Green, M (1990) Chemical synthesis of human papillomavirus type 16 E7 oncoprotein: autonomous protein domains for induction of cellular DNA synthesis and for trans activation. J Virol 64:6121-9

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