The Yale WRHR Center was established ten years ago with the objective of training obstetrician/ gynecologists as physician-scientists in women's reproductive science in order to mentor future leaders in this critical field. It has been extremel successful. Currently, the Yale Program has mentored eight Scholars of which six have graduated and two are currently in training. All of the graduated Scholars are pursuing independent academic careers and have been successful in obtaining research funds. Furthermore, the Scholars who have graduated from the Yale program have become or are becoming leaders in their respective fields. Every one of the first group of Scholars, is at the present time in a leadership position (Division Director) in major academic institution in the United States. This proposal is a continuation of this well-established, rigorous, step-wise research-training program. The Principal Investigator/Program Director (PD/PI) and Research Director (RD) will monitor the Scholars' academic progress toward research independence. We identify prospective scholars from our residents, subspecialty fellows, and junior faculty, as well as national networking by the PD/PI and RD and advertisements in professional journals, letters to Program Directors and Chairs and postings at national meetings. Our selection committee chooses WRHR Scholars who exhibit exceptional promise and commitment to a career in women's health research. The PD/PI, RD, and Advisory Committee are directly involved in the training, evaluation and academic development of each WRHR Scholar. Mentors are experienced in career development and are outstanding scientists in fields related to Women's Reproductive Health. Core training in basic lab techniques and molecular biology along with a didactic program are required for all WRHR Scholars and include instruction in the responsible and ethical conduct of research. Each Scholar is assigned departmental laboratory space with access to shared teaching and training cores. In order to pursue career development 75% of Scholars time is devoted to research, plus research support for 2-5 years to underwrite costs while they obtain preliminary data and develop grant applications. Scholars enter the Department of Ob/Gyn as Assistant Professors, with appropriate office and support staff. Clinical duties and responsibilities relate directly to research interests. The Yale WRHR program has proven to be extremely popular allowing us to rapidly fill open positions with excellent candidates. The overall impact and effectiveness of the program and its quality are evidenced by the success of all of our scholars. Yale seeks to retain, as faculty, Scholars who successfully complete the individualized training program at Yale and who have made significant progress toward independent funding.

Public Health Relevance

Yale WRHR Center provides the Scholars with the training required to contribute in an active, productive and significant way to improve women's health by developing new areas of research and new therapeutic approaches to enhance our understanding of the pathophysiology of diseases affecting women's well-being.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12HD047018-13
Application #
9307886
Study Section
Special Emphasis Panel (ZHD1)
Program Officer
Mazloomdoost, Donna
Project Start
2004-05-01
Project End
2020-06-30
Budget Start
2017-07-01
Budget End
2018-06-30
Support Year
13
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Yale University
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Mak, Winifred; Xia, Jing; Cheng, Ee-Chun et al. (2018) A role of Pumilio 1 in mammalian oocyte maturation and maternal phase of embryogenesis. Cell Biosci 8:54
Li, Fei; Alderman 3rd, Myles H; Tal, Aya et al. (2018) Hematogenous Dissemination of Mesenchymal Stem Cells from Endometriosis. Stem Cells 36:881-890
Collins, Stephen C; Xu, Xiao; Mak, Winifred (2017) Cost-effectiveness of preimplantation genetic screening for women older than 37 undergoing in vitro fertilization. J Assist Reprod Genet 34:1515-1522
Mak, Winifred; Kondapalli, Laxmi A; Celia, Gerard et al. (2016) Natural cycle IVF reduces the risk of low birthweight infants compared with conventional stimulated IVF. Hum Reprod 31:789-94
Grimstad, F W; Nangia, Ajay K; Luke, B et al. (2016) Use of ICSI in IVF cycles in women with tubal ligation does not improve pregnancy or live birth rates. Hum Reprod 31:2750-2755
Whicker, Margaret E; Lin, Z Ping; Hanna, Ruth et al. (2016) MK-2206 sensitizes BRCA-deficient epithelial ovarian adenocarcinoma to cisplatin and olaparib. BMC Cancer 16:550
Ishiguro, Kimiko; Zhu, Yong-Lian; Lin, Z Ping et al. (2016) Cataloging antineoplastic agents according to their effectiveness against platinum-resistant and platinum-sensitive ovarian carcinoma cell lines. J Transl Sci 2:117-124
Ratner, Elena S; Zhu, Yong-Lian; Penketh, Philip G et al. (2016) Triapine potentiates platinum-based combination therapy by disruption of homologous recombination repair. Br J Cancer 114:777-86
Mak, Winifred; Fang, Caodi; Holden, Tobias et al. (2016) An Important Role of Pumilio 1 in Regulating the Development of the Mammalian Female Germline. Biol Reprod 94:134
Silasi, Michelle; Cardenas, Ingrid; Kwon, Ja-Young et al. (2015) Viral infections during pregnancy. Am J Reprod Immunol 73:199-213

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