The Yale Women's Reproductive Health Research (WRHR) Career Development Center was established 15 years ago. Its objective is to provide advanced training of Ob/Gyns in basic, translational and/or clinical research in Women's Reproductive Health, under the guidance of skilled scientific Mentors, in order to produce the next generation of physician-scientists and leaders in the field. It has been extremely successful. So far, the Yale Program has mentored 10 Scholars, of which 8 have graduated, and 2 are currently in-training. All our original graduated Scholars are Division Directors in Ob/Gyn Departments at major US academic institutions, and have been successful in obtaining NIH research support. Our more recently graduated Scholars have become/are becoming leaders in their respective fields and also include Division and Fellowship Directors. All hold faculty positions in Ob/Gyn Departments at major US academic institutions and have obtained research funding. This proposal is a continuation of this well-established, rigorous, step-wise research-training program. The Program Director/Principal Investigator (PD/PI) and Research Director (RD) monitor the Scholars? academic progress toward independence. We identify prospective scholars from our residents and subspecialty fellows, as well as by national networking; advertisements in professional journals; letters to Program Directors and Chairs; and postings at national meetings. Our Advisory Committee chooses Scholars exhibiting exceptional promise and commitment to a career in Women's Reproductive Health Research. The PD/PI, RD, and Advisory Committee are directly involved in the training, evaluation and academic development of each Scholar, and monitor their progress toward research independence. Mentors are experienced in career development and are outstanding scientists in fields related to Women's Reproductive Health. Core training laboratories in Molecular and Cellular Biology along with a didactic program are required for all Scholars, including instruction in the responsible conduct of research. There are two Scholars in the Department at any given time, with each assigned laboratory space with access to shared teaching and training cores. In order to pursue career development, at least 75% of the Scholars' time is devoted to research, plus support for up to 5 years to underwrite costs while they obtain preliminary data for grant applications. During this time, our goal is for Scholars to obtain competitive NIH and other funding sufficient to suppport an independent academic career. Scholars enter the Department as Assistant Professors, with appropriate office space and support staff. Clinical duties and responsibilities relate directly to their research interests. The Yale WRHR program is extremely popular and competitive allowing us to rapidly fill open positions with outstanding candidates. The overall impact and effectiveness of the program and its quality are evidenced by the success of all of our scholars. The Yale WRHR Center aims to foster Scholars' development into independent investigators. Yale seeks to retain, as faculty, Scholars who successfully complete this individualized training program and who have made significant progress toward independent funding.

Public Health Relevance

The Yale Women's Reproductive Health Research (WRHR) Career Development Center provides advanced training of obstetricians and gynecologists in basic, translational, and/or clinical science in order to produce the next generation of highly skilled physician-scientists and leaders to contribute to the improvement of women's reproductive health.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
2K12HD047018-16
Application #
10063237
Study Section
Special Emphasis Panel (ZHD1)
Program Officer
Mazloomdoost, Donna
Project Start
2004-05-01
Project End
2025-06-30
Budget Start
2020-08-01
Budget End
2021-06-30
Support Year
16
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Yale University
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Mak, Winifred; Xia, Jing; Cheng, Ee-Chun et al. (2018) A role of Pumilio 1 in mammalian oocyte maturation and maternal phase of embryogenesis. Cell Biosci 8:54
Li, Fei; Alderman 3rd, Myles H; Tal, Aya et al. (2018) Hematogenous Dissemination of Mesenchymal Stem Cells from Endometriosis. Stem Cells 36:881-890
Collins, Stephen C; Xu, Xiao; Mak, Winifred (2017) Cost-effectiveness of preimplantation genetic screening for women older than 37 undergoing in vitro fertilization. J Assist Reprod Genet 34:1515-1522
Mak, Winifred; Kondapalli, Laxmi A; Celia, Gerard et al. (2016) Natural cycle IVF reduces the risk of low birthweight infants compared with conventional stimulated IVF. Hum Reprod 31:789-94
Grimstad, F W; Nangia, Ajay K; Luke, B et al. (2016) Use of ICSI in IVF cycles in women with tubal ligation does not improve pregnancy or live birth rates. Hum Reprod 31:2750-2755
Whicker, Margaret E; Lin, Z Ping; Hanna, Ruth et al. (2016) MK-2206 sensitizes BRCA-deficient epithelial ovarian adenocarcinoma to cisplatin and olaparib. BMC Cancer 16:550
Ishiguro, Kimiko; Zhu, Yong-Lian; Lin, Z Ping et al. (2016) Cataloging antineoplastic agents according to their effectiveness against platinum-resistant and platinum-sensitive ovarian carcinoma cell lines. J Transl Sci 2:117-124
Ratner, Elena S; Zhu, Yong-Lian; Penketh, Philip G et al. (2016) Triapine potentiates platinum-based combination therapy by disruption of homologous recombination repair. Br J Cancer 114:777-86
Mak, Winifred; Fang, Caodi; Holden, Tobias et al. (2016) An Important Role of Pumilio 1 in Regulating the Development of the Mammalian Female Germline. Biol Reprod 94:134
Silasi, Michelle; Cardenas, Ingrid; Kwon, Ja-Young et al. (2015) Viral infections during pregnancy. Am J Reprod Immunol 73:199-213

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