Abstract

We propose to provide training for dentists which will enable them to become independent clinical investigators. We have had a training program in Oral Biology which began in 1964 and has resulted in the training of 21 individuals at the doctoral level, and 20 others including those receiving M.S. degrees and postdoctoral fellows to date. For the last 16 years we have also offered training to dentists which combined the Ph.D. in Oral Biology with clinical training leading to certification in Periodontology (14 trainees), Dental Radiology (1 trainee), and Endodontics (1 trainee). We now propose to strengthen both of these components, that is the basic science training at the doctoral level and the clinical training, and to add another component; training under supervision in clinical investigation with an emphasis on the study of oral diseases. This third component, clinical investigation, will engage the trainee in application of basic science information and clinical training to a clinical problem related to the oral cavity.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Unknown (K16)
Project #
5K16DE000158-05
Application #
3088708
Study Section
(SRC)
Project Start
1985-07-01
Project End
1990-06-30
Budget Start
1989-07-01
Budget End
1990-06-30
Support Year
5
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
State University of New York at Buffalo
Department
Type
Schools of Dentistry/Oral Hygn
DUNS #
038633251
City
Buffalo
State
NY
Country
United States
Zip Code
14260

  Publications

Krebs, Linda J; Wang, Xiaopeng; Nagy, Atilla et al. (2002) Bombesin and epidermal growth factor potentiate the effect of cytotoxic LH-RH analog AN-152 in vitro. Int J Oncol 21:1325-9
Krebs, Linda J; Wang, Xiaopeng; Nagy, Attila et al. (2002) A conjugate of doxorubicin and an analog of Luteinizing Hormone-Releasing Hormone shows increased efficacy against oral and laryngeal cancers. Oral Oncol 38:657-663
Rogers, J D; Scannapieco, F A (2001) RegG, a CcpA homolog, participates in regulation of amylase-binding protein A gene (abpA) expression in Streptococcus gordonii. J Bacteriol 183:3521-5
Krebs, L J; Wang, X; Pudavar, H E et al. (2000) Regulation of targeted chemotherapy with cytotoxic lutenizing hormone-releasing hormone analogue by epidermal growth factor. Cancer Res 60:4194-9
Malek, R; Fisher, J G; Caleca, A et al. (1994) Inactivation of the Porphyromonas gingivalis fimA gene blocks periodontal damage in gnotobiotic rats. J Bacteriol 176:1052-9
Dolce, C; Anguita, J; Brinkley, L et al. (1994) Effects of sialoadenectomy and exogenous EGF on molar drift and orthodontic tooth movement in rats. Am J Physiol 266:E731-8
Stephan, E B; Dziak, R (1994) Effects of genistein, tyrphostin, and pertussis toxin on EGF-induced mitogenesis in primary culture and clonal osteoblastic cells. Calcif Tissue Int 54:409-13
Grossi, S G; Zambon, J J; Ho, A W et al. (1994) Assessment of risk for periodontal disease. I. Risk indicators for attachment loss. J Periodontol 65:260-7
Winston, J L; Chen, C K; Neiders, M E et al. (1993) Membrane protein expression by Actinobacillus actinomycetemcomitans in response to iron availability. J Dent Res 72:1366-73
Sharma, A; Sojar, H T; Lee, J Y et al. (1993) Expression of a functional Porphyromonas gingivalis fimbrillin polypeptide in Escherichia coli: purification, physicochemical and immunochemical characterization, and binding characteristics. Infect Immun 61:3570-3

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