Abstract

Actinobacillus actinomycetemcomitans has been strongly implicated as a primary periodontal pathogen in localized juvenile periodontitis(LJP). Recent evidence has suggested that, in patients with LJP and possibly refractory periodontitis, the primary IgG antibody response is directed against the endotoxin produced by this organism. Specifically, IgG antibodies are produced against the O-polysaccharide moiety of the LPS in Aa. However, the IgG generated is principally of the IgG2 subclass. This subclass typically exhibits poor opsonic antibody which may therefore minimize the protective nature of the immune response. One of the long term objectives of proposed studies is to develop a conjugated vaccine for LJP patients with world help generate protective antibodies that may benefit the LJP and/or RPP patient with respect to control of Aa infection.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Unknown (K16)
Project #
5K16DE000158-08
Application #
3839112
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
8
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
State University of New York at Buffalo
Department
Type
DUNS #
038633251
City
Buffalo
State
NY
Country
United States
Zip Code
14260

  Publications

Krebs, Linda J; Wang, Xiaopeng; Nagy, Atilla et al. (2002) Bombesin and epidermal growth factor potentiate the effect of cytotoxic LH-RH analog AN-152 in vitro. Int J Oncol 21:1325-9
Krebs, Linda J; Wang, Xiaopeng; Nagy, Attila et al. (2002) A conjugate of doxorubicin and an analog of Luteinizing Hormone-Releasing Hormone shows increased efficacy against oral and laryngeal cancers. Oral Oncol 38:657-663
Rogers, J D; Scannapieco, F A (2001) RegG, a CcpA homolog, participates in regulation of amylase-binding protein A gene (abpA) expression in Streptococcus gordonii. J Bacteriol 183:3521-5
Krebs, L J; Wang, X; Pudavar, H E et al. (2000) Regulation of targeted chemotherapy with cytotoxic lutenizing hormone-releasing hormone analogue by epidermal growth factor. Cancer Res 60:4194-9
Malek, R; Fisher, J G; Caleca, A et al. (1994) Inactivation of the Porphyromonas gingivalis fimA gene blocks periodontal damage in gnotobiotic rats. J Bacteriol 176:1052-9
Dolce, C; Anguita, J; Brinkley, L et al. (1994) Effects of sialoadenectomy and exogenous EGF on molar drift and orthodontic tooth movement in rats. Am J Physiol 266:E731-8
Stephan, E B; Dziak, R (1994) Effects of genistein, tyrphostin, and pertussis toxin on EGF-induced mitogenesis in primary culture and clonal osteoblastic cells. Calcif Tissue Int 54:409-13
Grossi, S G; Zambon, J J; Ho, A W et al. (1994) Assessment of risk for periodontal disease. I. Risk indicators for attachment loss. J Periodontol 65:260-7
Winston, J L; Chen, C K; Neiders, M E et al. (1993) Membrane protein expression by Actinobacillus actinomycetemcomitans in response to iron availability. J Dent Res 72:1366-73
Sharma, A; Sojar, H T; Lee, J Y et al. (1993) Expression of a functional Porphyromonas gingivalis fimbrillin polypeptide in Escherichia coli: purification, physicochemical and immunochemical characterization, and binding characteristics. Infect Immun 61:3570-3

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