We propose to continue to provide training for dentists which will enable them to become independent clinical investigators addressing problems of importance to oral health. The training program will consist of three components: (1) training in basic sciences, most often leading to a Ph.D. in Oral Biology but may also take other forms such as a Ph.D. in other departments, (2) clinical training most often leading to certification in the clinical specialties of periodontics, Endodontics, Fixed or Removal Prosthodontics or Orthodontics. The third component is clinical investigation in which the candidate applies basic science knowledge to a problem of clinical importance in oral health. The basic science phase will lead to completion of the Ph.D., the clinical portion most often will lead to certification, and the clinical investigation phase will be completed when the courses relevant to this phase and research in a clinical investigation is accomplished independent from research related to the basic science or Ph.D. work. The entire Program will be carried out under the close supervision of a primary mentor who will be the candidate's Ph.D. supervisor. Also, a secondary mentor may be involved who will aid in overseeing the clinical investigation. Each candidate's progress will be monitored with a Student Advisory Committee, and the overall Program will be directed by an Academic Advisory Board made up of representatives from each of the basic science and clinical departments who will be training the candidate. There will also be an External Review Board comprised of prominent scientist/educators from outside the University who will provide advice on the overall Program. Continuation support for the Program is sought from the National Institutes of Health by virtue of the Dentist Scientist Award, however, additional support will be provided by the Dental School of the State University of New York at Buffalo for completion of training if the award is not renewed or if training takes longer than five years. Training will be carried out primarily at the State University of New York at Buffalo School of Dental Medicine, however, mentors from the School of Medicine, School of Pharmacy and the Roswell Park Cancer Institute will also be involved in training where appropriate. Most of the clinical training will take place in the Dental Clinics of the Dental School and the affiliated hospitals.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Unknown (K16)
Project #
3K16DE000158-10S1
Application #
2128647
Study Section
Special Emphasis Panel (SRC (01))
Project Start
1985-07-01
Project End
1996-06-30
Budget Start
1994-07-01
Budget End
1996-06-30
Support Year
10
Fiscal Year
1995
Total Cost
Indirect Cost
Name
State University of New York at Buffalo
Department
Dentistry
Type
Schools of Dentistry
DUNS #
038633251
City
Buffalo
State
NY
Country
United States
Zip Code
14260
Krebs, Linda J; Wang, Xiaopeng; Nagy, Atilla et al. (2002) Bombesin and epidermal growth factor potentiate the effect of cytotoxic LH-RH analog AN-152 in vitro. Int J Oncol 21:1325-9
Krebs, Linda J; Wang, Xiaopeng; Nagy, Attila et al. (2002) A conjugate of doxorubicin and an analog of Luteinizing Hormone-Releasing Hormone shows increased efficacy against oral and laryngeal cancers. Oral Oncol 38:657-663
Rogers, J D; Scannapieco, F A (2001) RegG, a CcpA homolog, participates in regulation of amylase-binding protein A gene (abpA) expression in Streptococcus gordonii. J Bacteriol 183:3521-5
Krebs, L J; Wang, X; Pudavar, H E et al. (2000) Regulation of targeted chemotherapy with cytotoxic lutenizing hormone-releasing hormone analogue by epidermal growth factor. Cancer Res 60:4194-9
Malek, R; Fisher, J G; Caleca, A et al. (1994) Inactivation of the Porphyromonas gingivalis fimA gene blocks periodontal damage in gnotobiotic rats. J Bacteriol 176:1052-9
Dolce, C; Anguita, J; Brinkley, L et al. (1994) Effects of sialoadenectomy and exogenous EGF on molar drift and orthodontic tooth movement in rats. Am J Physiol 266:E731-8
Stephan, E B; Dziak, R (1994) Effects of genistein, tyrphostin, and pertussis toxin on EGF-induced mitogenesis in primary culture and clonal osteoblastic cells. Calcif Tissue Int 54:409-13
Grossi, S G; Zambon, J J; Ho, A W et al. (1994) Assessment of risk for periodontal disease. I. Risk indicators for attachment loss. J Periodontol 65:260-7
Winston, J L; Chen, C K; Neiders, M E et al. (1993) Membrane protein expression by Actinobacillus actinomycetemcomitans in response to iron availability. J Dent Res 72:1366-73
Sharma, A; Sojar, H T; Lee, J Y et al. (1993) Expression of a functional Porphyromonas gingivalis fimbrillin polypeptide in Escherichia coli: purification, physicochemical and immunochemical characterization, and binding characteristics. Infect Immun 61:3570-3

Showing the most recent 10 out of 24 publications