The candidate, Dr. Guadalupe Garcia-Tsao, is Associate Professor in the Department of Internal Medicine at the Yale University School of Medicine. She has devoted her career to patient-oriented research (POR) in the area of cirrhosis and in complications. She has been involved in a wide range of POR, from descriptive studies to multicenter randomized clinical trials. Her studies in the area of varices, variceal hemorrhage, ascites and spontaneous bacterial peritonitis have made significant contributions to the management of patients with cirrhosis, the sixth leading cause of death in the United States in individuals between the ages of 25 and 65, the productive years of life. She is recognized as a clinical research in the area of portal hypertension as attested by invitations to chair abstract selection committees and to serve as session moderator at important scientific meetings, as well as invitations to write editorials, review articles and to become panel member at international consensus panels. Ascites is one of the main complications of cirrhosis and portal hypertension and Dr. Garcia-Tsao's short tem goals are to focus on this complication. One of these goals is to implement a randomized trial comparing the transjugular intrahepatic porto-systemic shunt with serial large-volume paracenteses in the treatment of patients with refractory ascites. This multicenter trial, partially funded by a VA Merit Review, will analyze not only differences in efficacy but also differences in quality of life and cost, and the results can potentially change current standards of care for patients with cirrhosis. R. Garcia-Tsao's long-term career goals are to continue to perform POR focused on prophylactic therapy and identification of prognostic factors in chronic liver disease as well as furthering her training in health services research. Dr. Garcia-Tsao has devoted a great deal of effort toward mentoring beginning clinical investigators in POR, especially in her capacity as co-Director of the Liver Center's Clinical Core. Yale University is one of the major teaching and research institutions of the United States and as such has well-established research and educational resources that will continue to be utilized by the candidate. The proposed award will allow her to carry out her research and mentoring objectives successful so that she can continue to make significant contributions in the field of cirrhosis and its complications.
| Jangouk, Parastoo; Turco, Laura; De Oliveira, Ana et al. (2017) Validating, deconstructing and refining Baveno criteria for ruling out high-risk varices in patients with compensated cirrhosis. Liver Int 37:1177-1183 |
| Albillos, Agustín; Zamora, Javier; Martínez, Javier et al. (2017) Stratifying risk in the prevention of recurrent variceal hemorrhage: Results of an individual patient meta-analysis. Hepatology 66:1219-1231 |
| Fortune, Brett; Garcia-Tsao, Guadalupe (2014) Current Management Strategies for Acute Esophageal Variceal Hemorrhage. Curr Hepatol Rep 13:35-42 |
| Belcher, Justin M; Parikh, Chirag R; Garcia-Tsao, Guadalupe (2013) Acute kidney injury in patients with cirrhosis: perils and promise. Clin Gastroenterol Hepatol 11:1550-8 |
| Tandon, Puneeta; Delisle, Angela; Topal, Jeffrey E et al. (2012) High prevalence of antibiotic-resistant bacterial infections among patients with cirrhosis at a US liver center. Clin Gastroenterol Hepatol 10:1291-8 |
| Sethasine, Supatsri; Jain, Dhanpat; Groszmann, Roberto J et al. (2012) Quantitative histological-hemodynamic correlations in cirrhosis. Hepatology 55:1146-53 |
| Bari, Khurram; Miñano, Cecilia; Shea, Martha et al. (2012) The combination of octreotide and midodrine is not superior to albumin in preventing recurrence of ascites after large-volume paracentesis. Clin Gastroenterol Hepatol 10:1169-75 |
| Zipprich, Alexander; Garcia-Tsao, Guadalupe; Rogowski, Sebastian et al. (2012) Prognostic indicators of survival in patients with compensated and decompensated cirrhosis. Liver Int 32:1407-14 |
| Opio, Christopher Kenneth; Garcia-Tsao, Guadalupe (2011) Managing varices: drugs, bands, and shunts. Gastroenterol Clin North Am 40:561-79 |
| Berzigotti, Annalisa; Garcia-Tsao, Guadalupe; Bosch, Jaime et al. (2011) Obesity is an independent risk factor for clinical decompensation in patients with cirrhosis. Hepatology 54:555-61 |
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