The candidate is currently a Professor of Medicine at the University of Washington. The protected time provided during the initial funding period has enabled the candidate to achieve national and international recognition as a mentor and patient-oriented researcher. The candidate has successfully obtained independent NIH research funding, has established a track record of successful mentorship and is an active and sought-after mentor in patient-oriented research in liver disease for several trainees at various levels, including recipients of K23 and other career development awards. The applicant has the following career goals for the proposed period of funding: 1 To increase the translational laboratory component of his research in the area of iron overload disorders and nonalcoholic steatohepatitis. 2. To secure long-term funding via RO1 grants to maintain the productivity achieved with the K24 award. 3. To identify and mentor trainees at all levels to help increase the number of future investigators in patient-oriented research and to be an advocate of patient-oriented research. 4. To support patient-oriented research in hepatology for junior investigators at the University of Washington Medical Center via liver-disease specific registries in hepatititis B, cholestatic and genetic liver diseases. The candidate will further develop his now well-established patient-oriented research program in the area of iron overload disorders and nonalcoholic fatty liver disease, both of which are common metabolic liver disorders leading to significant morbidity. Hereditary hemochromatosis encompasses a range of genetic iron overload disorders that involve mutations in a number of genes known to be involved in iron transport. Nonalcoholic fatty liver disease has become an increasingly prominent liver disease;iron overload and HFE mutations are also being recognized as contributing factors to hepatitis C, end-stage liver disease and nonalcoholic steatohepatitis. The University of Washington is the only referral center for liver disease in a five state region and has several multidisciplinary programs and centers to support patient-oriented research;therefore there is an excellent academic and institutional environment to enable the candidate to achieve his patient oriented research goals. The candidate thus has adequate ongoing research projects, mentees, extramural funding, and strong institutional support, facilities and resources to ensure success as a mentor and patient-oriented researcher.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24DK002957-09
Application #
7634542
Study Section
Special Emphasis Panel (ZDK1-GRB-3 (J2))
Program Officer
Podskalny, Judith M,
Project Start
2001-07-01
Project End
2011-06-30
Budget Start
2009-07-01
Budget End
2010-06-30
Support Year
9
Fiscal Year
2009
Total Cost
$176,079
Indirect Cost
Name
Benaroya Research Institute at Virginia Mason
Department
Type
DUNS #
076647908
City
Seattle
State
WA
Country
United States
Zip Code
98101
Nelson, J E; Handa, P; Aouizerat, B et al. (2016) Increased parenchymal damage and steatohepatitis in Caucasian non-alcoholic fatty liver disease patients with common IL1B and IL6 polymorphisms. Aliment Pharmacol Ther 44:1253-1264
Kratz, Mario; Marcovina, Santica; Nelson, James E et al. (2014) Dairy fat intake is associated with glucose tolerance, hepatic and systemic insulin sensitivity, and liver fat but not ?-cell function in humans. Am J Clin Nutr 99:1385-96
Messner, Donald J; Rhieu, Byung Han; Kowdley, Kris V (2013) Iron overload causes oxidative stress and impaired insulin signaling in AML-12 hepatocytes. Dig Dis Sci 58:1899-908
Maliken, Bryan D; Nelson, James E; Klintworth, Heather M et al. (2013) Hepatic reticuloendothelial system cell iron deposition is associated with increased apoptosis in nonalcoholic fatty liver disease. Hepatology 57:1806-13
Vuppalanchi, Raj; Gould, Robert J; Wilson, Laura A et al. (2012) Clinical significance of serum autoantibodies in patients with NAFLD: results from the nonalcoholic steatohepatitis clinical research network. Hepatol Int 6:379-85
Maliken, Bryan D; Avrin, William F; Nelson, James E et al. (2012) Room-temperature susceptometry predicts biopsy-determined hepatic iron in patients with elevated serum ferritin. Ann Hepatol 11:77-84
Kowdley, Kris V; Belt, Patricia; Wilson, Laura A et al. (2012) Serum ferritin is an independent predictor of histologic severity and advanced fibrosis in patients with nonalcoholic fatty liver disease. Hepatology 55:77-85
Li, Yu; Kowdley, Kris V (2012) Method for microRNA isolation from clinical serum samples. Anal Biochem 431:69-75
Siddique, Asma; Kowdley, Kris V (2012) Approach to a patient with elevated serum alkaline phosphatase. Clin Liver Dis 16:199-229
Li, Yu; Kowdley, Kris V (2012) MicroRNAs in common human diseases. Genomics Proteomics Bioinformatics 10:246-53

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