Abstract

The intervention studies of the Claude D. Pepper Older Americans Independence Center (OAIC) all are centered around the broad theme that losses of axial mobility (mobility of the neck and back) contribute to functional limitations. The investigations have as one of their major hypotheses that improvements in axial mobility will lead to improvements of specific aspects of function. Each investigation includes an exercise intervention component with exercises directed at least in part to axial mobility. One of the OAIC intervention studies and the measurements for a second study are carried out in the GCRC. The first study is a randomized clinical trial comparing exercise to no exercise for participants who are in the early and middle stages of Parkinson's disease (PD). The second is a randomized clinical trial comparing a traditional aerobic conditioning program to an aerobic conditioning program plus an axial mobility exercise program for sedentary community dwelling older individuals.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
2M01RR000030-35
Application #
5215585
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
35
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

Askie, Lisa M; Darlow, Brian A; Finer, Neil et al. (2018) Association Between Oxygen Saturation Targeting and Death or Disability in Extremely Preterm Infants in the Neonatal Oxygenation Prospective Meta-analysis Collaboration. JAMA 319:2190-2201
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Ahmed, Zuhayer; Prasad, Indrajit; Rahman, Hafizur et al. (2016) A Male with Extreme Subcutaneous Insulin Resistance: A Case Report. Rom J Diabetes Nutr Metab Dis 23:209-213
Phelps, Dale L; Ward, Robert M; Williams, Rick L et al. (2016) Safety and pharmacokinetics of multiple dose myo-inositol in preterm infants. Pediatr Res 80:209-17
Stafford-Smith, Mark; Li, Yi-Ju; Mathew, Joseph P et al. (2015) Genome-wide association study of acute kidney injury after coronary bypass graft surgery identifies susceptibility loci. Kidney Int 88:823-32
Paine, Nicola J; Watkins, Lana L; Blumenthal, James A et al. (2015) Association of depressive and anxiety symptoms with 24-hour urinary catecholamines in individuals with untreated high blood pressure. Psychosom Med 77:136-44

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