RS25560 is a potent inhibitor of isolated rat and human DBH (dopamine B-hydroxylase) enzyme. Inhibition of this enzyme affects sympathetic tone by decreasing norepinephrine and increasing dopamine release from nerve terminals in response to sympathetic nerve stimulation. Since the elevated sympathetic tone in congestive heart failure is believed to contribute to the progression of the disease and to its poor prognosis, a DBH inhibitor has the potential for being a useful addition to the current pharmacologic treatment of this condition. The significance of this study is to provide a potential new therapy for the chronic treatment of congestive heart failure. This is the first study to evaluate RS-25560 in men who have been diagnosed with congestive heart failure, and is designed to determine the safety, tolerability, pharmacokinetics and pharmacodynamics of the compound in these patients. Each patient will be randomized to receive either an oral solution of suspension of RS25560, or matching placebo. If RS-25560 is found to be effective in men, the sponsor may conduct future studies in women with congestive heart failure.

Project Start
1997-02-10
Project End
1997-11-30
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
37
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Type
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294
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