This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Since this study's inception, we have made significant progress in fine-tuning all study procedures, and are on schedule with our recruitment goals of reducing a total of 50 obese women (25 Black and 25 White) to the normal-weight post-obese state and comparing them with 50 never-obese control subjects. African-American women became significantly less physically active after weight loss in comparison to an increase in activity of the Caucasian women. African-American women also became less fit after weight loss, demonstrated as having reductions in VO2max, compared to improved fitness of the Caucasian women. Energy Expenditure and Body Composition. Overall, sleeping energy expenditure was appropriate for the reduced body mass after weight loss. That is, there was no evidence for greater energy conservation in the weight-reduced women. However, significant differences in sleeping energy expenditure and partitioning of lean tissue were seen between African-American women and Caucasian women. African-American women had lower sleeping energy expenditure, max VO2 and trunk lean tissue, despite having elevated limb lean tissue. Differences in sleeping energy expenditure between the two races disappeared after adjusting for trunk lean tissue, suggesting that lower metabolically active organ mass may be the explanation for lower sleeping energy requirements in African-American women. Abdominal fat distribution changes with weight loss differed between the races. African-American women lost significantly greater amounts of subcutaneous abdominal fat tissue and less intra-abdominal fat tissue relative to the losses of the Caucasian women.
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