EXCEED THE SPACE PROVIDED. The proposed UAB Pittman GCRC renewal application is designed to serve the needs of an outstanding clinical research faculty and to facilitate and promote growth in clinical research at UAB in both the short and long term. A key to this ongoing growth is a much-improved infrastructure that providesstate-of-the-art methodology through its scientific cores. A new director (Moreland) was appointed in 1999 and under his aggressive leadership significant changes have occurred. Four new scientific units/cores have been added: 1) Informatics (J. Allison), 2) Molecular Genetics (Edberg), 3) Statistical Genetics (D. Allison) and 4) Pediatrics Satellite Clinic (Kimberlin). Six new training programs have .also been initiated: 1)NIH K30 (Moreland); includes Clinical Research Training Program and MSPH in Clinical Research (Howard and Kaslow); 2) Clinical Investigator Fellowship Award (Moreland); 3) Residency Training Program (Kimberlin); 4) Medical Student Summer Research Program (Kilby); 5) Year-Long Mentored Medical Student Research Program (Kilby); and 6) Informatics Core Year-Long Mentored Medical Student Program (J. Allison). Outpatient clinics have been established at The Kirklin Clinic and Children's Hospital of Alabama, and new and emerging affiliations have been established with scientific programs outside the GCRC. Since 1998, the Institution has provided approximately $4 million to support the GCRC. This application demonstrates the important role that interdisciplinary research centers play in integrating the basic and clinical sciences and of the potential they provide for stimulating future GCRC studies. The eight site visit presentationsinclude established senior (LoBuglio, Moreland, Alarcon, Azziz, Guay-Woodford and Weinsier) and junior (Clancy and Gower) faculty investigators. Exemplifying the GCRC's emphasis on diversity, four of these presentations focus on the African-American populations, which historically have been underrepresented in research studies and to which UAB investigators have excellent access. Ninety-two GCRC protocols, involving 156 investigators are described with five being highlighted as an indication of the cutting-edge research conducted at UAB (Research Accomplishments Section IV.A.). Continued growth in rigorous scientific clinical research at UAB is assured through a broad-based, talented and committed faculty of investigators, a strong institutional commitment and scientific and oversight support by the Administrative Unit.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000032-47
Application #
7191758
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Program Officer
Obrams, G Iris
Project Start
1978-12-01
Project End
2008-05-31
Budget Start
2007-03-01
Budget End
2008-05-31
Support Year
47
Fiscal Year
2007
Total Cost
$3,433,200
Indirect Cost
Name
University of Alabama Birmingham
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Yu, Alan S L; Shen, Chengli; Landsittel, Douglas P et al. (2018) Baseline total kidney volume and the rate of kidney growth are associated with chronic kidney disease progression in Autosomal Dominant Polycystic Kidney Disease. Kidney Int 93:691-699
Askie, Lisa M; Darlow, Brian A; Finer, Neil et al. (2018) Association Between Oxygen Saturation Targeting and Death or Disability in Extremely Preterm Infants in the Neonatal Oxygenation Prospective Meta-analysis Collaboration. JAMA 319:2190-2201
McKenzie, Katelyn A; El Ters, Mirelle; Torres, Vicente E et al. (2018) Relationship between caffeine intake and autosomal dominant polycystic kidney disease progression: a retrospective analysis using the CRISP cohort. BMC Nephrol 19:378
Srinivasan, Lakshmi; Page, Grier; Kirpalani, Haresh et al. (2017) Genome-wide association study of sepsis in extremely premature infants. Arch Dis Child Fetal Neonatal Ed 102:F439-F445
Morrison, Shannon A; Goss, Amy M; Azziz, Ricardo et al. (2017) Peri-muscular adipose tissue may play a unique role in determining insulin sensitivity/resistance in women with polycystic ovary syndrome. Hum Reprod 32:185-192
Shen, Chengli; Landsittel, Douglas; Irazabal, María V et al. (2017) Performance of the CKD-EPI Equation to Estimate GFR in a Longitudinal Study of Autosomal Dominant Polycystic Kidney Disease. Am J Kidney Dis 69:482-484
Denson, Lee A; McDonald, Scott A; Das, Abhik et al. (2017) Early Elevation in Interleukin-6 is Associated with Reduced Growth in Extremely Low Birth Weight Infants. Am J Perinatol 34:240-247
Kline, Timothy L; Korfiatis, Panagiotis; Edwards, Marie E et al. (2017) Image texture features predict renal function decline in patients with autosomal dominant polycystic kidney disease. Kidney Int 92:1206-1216
James, Jennifer; Munson, David; DeMauro, Sara B et al. (2017) Outcomes of Preterm Infants following Discussions about Withdrawal or Withholding of Life Support. J Pediatr 190:118-123.e4
Younge, Noelle; Goldstein, Ricki F; Bann, Carla M et al. (2017) Survival and Neurodevelopmental Outcomes among Periviable Infants. N Engl J Med 376:617-628

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