This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The purpose of this study is to create a registry of African Americans with early rheumatoid arthritis. The first phase of the registry, which enrollment ended on 9/29/06, was designed to systematically study African Americans with early rheumatoid arthritis in a longitudinal fashion (CLEAR I). The second phase of the registry, which began enrolling patients on 3/15/07, is designed to gather information from an additional 600 African Americans from 5 sites including UAB. UAB will recruit and enroll 250 African-American RA patients at any stage of Rheumatoid Arthritis and 125 healthy African American controls (CLEAR II). One of the primary aims of both phases of the CLEAR registry is to isolate and immortalize genomic DNA from patient blood samples for use in future studies. The Pittman GCRC Molecular Genetics Core Facility processes, stores, and isolates all genomic DNA obtained through this registry. The GCRC Informatics Core serves as the database repository using Teleform and other data management capabilities to manage the registry data.
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