This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The revised goal of this project is to compare brain activation in response to pictures of high-calorie food images, low-calorie food images, and control non-food images in fasted, healthy obese and normal-weight women. Areas of the brain examined will be parts of the reward system and associated brain regions, such as nucleus accumbens, orbitofrontal cortex, the insula, and the amygdale. The hypothesis being tested is that obese women will show greater reward system activation to pictures of high-calorie foods than normal-weight women. The GCRC was used to administer pregnancy tests to the subjects, as being pregnant was one of our exclusionary for the study, and to accurately measure their height and weight so that we could compute BMI, used to divide subjects into obese (BMI > 30) and normal groups (BMI 18.5-24.9). The results of this study will be used as baseline data for a larger project submitted to NIH for funding that will compare patterns of brain activation to high-calorie vs low-calorie food images in obese individuals part of UAB's EatRight program, studied before and after participation in the EatRight program.
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