This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In adults there is a close link between endothelial function and insulin sensitivity in both normotensive and hypertensive subjects. This relationship is thought possibly to play a role in the development of the 'metabolic syndrome' of insulin resistance, atherosclerosis, hypertension and type 2 diabetes. In this study we hypothesize that the positive correlation between insulin sensitivity and endothelial function seen in adults extends to normal adolescents and that differences in endothelial function may help explain: 1. Decreased insulin sensitivity in pubertal adolescents, 2. Decreased insulin sensitivity in African-Americans and To address these hypotheses we will use the forearm reactive hyperemic response to measure endothelial function and the stable labeled frequently sampled intravenous glucose tolerance test to measure insulin sensitivity. The following questions will be addressed 1. Are the percent changes in the forearm blood flow and/or vascular resistance following vascular occlusion (reactive hyperemic responses) positively related to insulin sensitivity in adolescents? 2. Are reactive hyperemic responses decreased in pubertal adolescents? 3. Are reactive hyperemic responses decreased in African-American compared to Caucasian adolescents?
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