This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Blood levels (plasma, RBC 5nucleotidase, and metallothionein) of zinc and 24-hr. urine excretion of zinc,considered together with clinical effect of a morning zinc supplement, suggest that children with attention-deficit/hyperactivity disorder (ADHD) may have a problem with zinc 'wasting'; rapid excretion after absorption. As an exploratory study to determine whether this hypothesis should be tested by a more definitive larger zinc PK study, up to 4 children with ADHD and 2 normal control children will have a 9-hour PK study with the same dose of zinc (15 mg, slightly more than the RDI) used in the previous study. Blood (from indwelling catheter) and urine samples will be collected at 1, 2, 4, 6, 7, and 9 hours following supplement ingestion and a low-zinc breakfast. Data analysis and interpretation will be by visual inspection of graphed results over time. The hypothesis is that for the ADHD children but not normal controls, the blood level will rise the first few hours, then drop back to baseline by 5 hours, accompanied by a peak of urinary excretion.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000034-48
Application #
7718679
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2007-12-01
Project End
2008-05-31
Budget Start
2007-12-01
Budget End
2008-05-31
Support Year
48
Fiscal Year
2008
Total Cost
$1,733
Indirect Cost
Name
Ohio State University
Department
Administration
Type
Schools of Medicine
DUNS #
832127323
City
Columbus
State
OH
Country
United States
Zip Code
43210
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