We will measure imunoreactive plasma leptin concentrations in 400 subjects under basal and experimental conditions and stratify results by body mass index (BMI) into four strata. We will then measure insulin sensitivity by clamp method in 64 subjects comprising individuals who are matched for age, gender, and BMI, but discordant for leptin secretor status {""""""""low secretors""""""""(plasma leptin<10ng.dl) and """"""""high secretors"""""""" (>20 ng/dl}.

Project Start
1997-12-01
Project End
1998-11-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
38
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Washington University
Department
Type
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
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