This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Insulin resistance is characterized by alterations in glucose and lipid metabolism. Leptin has been shown to have important effects in regulating glucose metabolism in rodents. However, the effect of leptin on glucose and lipid metabolism in subjects with insulin resistance in not known. The studies in this proposal are designed to elucidate the effect of lepitn treatment on basal and insulin-medicated whole-body glucose and lipid metabolism. Stable isotope tracer studies will be performed on 10 insulin-resistant subjects before and after a 14-day treatment with r-metHULeptin (0.3 mg/kg)
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