EXCEED THE SPACE PROVIDED.The Washington University General Clinical Research Center (GCRC) supports and facilities patient-orientedresearch and research training at Washington University School of Medicine. The GCRC includes an AdultUnit (outpatients and inpatients) in Barnard Hospital (operated by Barnes-Jewish Hospital) and a PediatricUnit (outpatients) in St. Louis Children's Hospital. It provides research nursing, bionutrition, core laboratory,informatics and biostatistical support. New ventures include a substantially expanded training programincluding development of a School-wide Division of Clinical Sciences, a new GCRC Pharma-cogenetics Core,planning for a clinical research imaging center and implementation of the GCRC Data and Safety MonitoringPlan. This application requests five years of support for the GCRC for its 44 ththrough 48 thyears. The 116protocols in this application are led by 46 GCRC principal investigators with appointments in the Departmentsof Medicine, Pediatrics, Surgery, Neurology, Psychiatry, Radiology, Pathology, Cell Biology and Physiology,Molecular Biology and Pharmacology and Genetics. While there are a broad range of approaches, manyprotocols require complex, research procedures including clamps, tolerance tests, tissue microdialysis, stableand radioactive kinetics (e.g., glucose, fatty acids, glycerol, amino acids, neuro-transmitters) and indirectcalorimetry as well as pharmacokinetics. Techniques used include genotype-phenotype correlation, an arrayof imaging methods including positron emission tomography, NMR imaging and spectroscopy and fMRI, andmass spectroscopy as well as tissue biopsies (muscle, fat, bronchi) for molecular analyses. Thediseases/disorders under study include AIDS (CNS and metabolic complications, treatment), Aging(sarcopenia, osteopenia, heart disease, caloric restriction), Alzheimer disease, Asthma (pathogenesis,management), Coronary Artery Disease (prevention, treatment), Cystic Fibrosis (neutrophil function, energybalance), Depression (CNS mechanisms, treatment), Diabetes (genetics, pathogenesis, prevention, islettransplantation, treatment, complications including hypoglycemia, psychosocial factors, heart disease),Dyslipidemias (fatty liver, treatment), End-Stage Renal Disease (bone disease, transplantation), Hypertension(LVH, treatment), Osteoporosis (genetic mechanisms, prevention, treatment), Obesity (pathogenesis,treatment, fatty liver, lipid metabolism, heart disease), Prostate Cancer (screening, bone disease), MultipleSclerosis (treatment), and Schizophrenia (treatment, complications) among others.
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