Clinical Research Center University of Washington: The Clinical Research Center (CRC) at the University of Washington has been in continuous operation since 1960. It comprises ten beds on unit 7 South at the University Hospital, served by 4.50 FATE administrative staff, 13.20 FATE research nurses and 4.25 dietary staff. Sixty-four ongoing and projected research protocols will be conducted on the CRC involving investigators from the Departments of: 1) Medicine, 2) Nuclear Medicine, 3) Obstetrics and gynecology, 4) Pediatrics, 5) Psychiatry, 6) Radiology and 7) Surgery. Forty-two principal investigators and eighty-six co-investigators will admit volunteers as either inpatients, daypatients (1-12 hr) and outpatients (< 1 hr) under approved protocols. By definition of the diverse disciplines represented above, the research protocols cover a wide spectrum, testing hypotheses related to normal physiologic controls and causes of common and esoteric diseases. In addition, several researchers have a focus on the efficacy and toxicity of drugs used in the treatment of a variety of diseases. The major areas of interest include the study of the secretion and action of insulin and related peptides in Type II diabetes mellitus, effects of nutrients in modifying lipids and hormonal release, risk factors of diabetes, identification and treatment of disorders of lipid metabolism, effects of drugs on progression of coronary artery disease, effects of exercise on weight loss and aging, treatment of hematologic disorders, identification of immunologic mechanisms in infection, diagnosis of Alzheimer's disease, study of hypothalamic pituitary gonadal axies in health and disease, and evaluation of new treatment for AIDS. This application documents the need for continuation of funding for 12 beds and 22.45 FATE for an additional 5 years.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000037-34
Application #
2280821
Study Section
General Clinical Research Centers Committee (CLR)
Project Start
1974-10-01
Project End
1994-11-30
Budget Start
1993-12-15
Budget End
1994-11-30
Support Year
34
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of Washington
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Courcoulas, Anita P; King, Wendy C; Belle, Steven H et al. (2018) Seven-Year Weight Trajectories and Health Outcomes in the Longitudinal Assessment of Bariatric Surgery (LABS) Study. JAMA Surg 153:427-434
Field, Alison E; Inge, Thomas H; Belle, Steven H et al. (2018) Association of Obesity Subtypes in the Longitudinal Assessment of Bariatric Surgery Study and 3-Year Postoperative Weight Change. Obesity (Silver Spring) 26:1931-1937
O'Rourke, Robert W; Johnson, Geoffrey S; Purnell, Jonathan Q et al. (2018) Serum biomarkers of inflammation and adiposity in the LABS cohort: associations with metabolic disease and surgical outcomes. Int J Obes (Lond) :
Cherrier, M M; Cross, D J; Higano, C S et al. (2018) Changes in cerebral metabolic activity in men undergoing androgen deprivation therapy for non-metastatic prostate cancer. Prostate Cancer Prostatic Dis 21:394-402
Duggan, Catherine; Baumgartner, Richard N; Baumgartner, Kathy B et al. (2018) Genetic variation in TNF?, PPAR?, and IRS-1 genes, and their association with breast-cancer survival in the HEAL cohort. Breast Cancer Res Treat 168:567-576
Han, Seung Jin; Boyko, Edward J; Kim, Soo Kyung et al. (2018) Association of Thigh Muscle Mass with Insulin Resistance and Incident Type 2 Diabetes Mellitus in Japanese Americans. Diabetes Metab J 42:488-495
Wander, Pandora L; Hayashi, Tomoshige; Sato, Kyoko Kogawa et al. (2018) Design and validation of a novel estimator of visceral adipose tissue area and comparison to existing adiposity surrogates. J Diabetes Complications 32:1062-1067
Purnell, Jonathan Q; Johnson, Geoffrey S; Wahed, Abdus S et al. (2018) Prospective evaluation of insulin and incretin dynamics in obese adults with and without diabetes for 2 years after Roux-en-Y gastric bypass. Diabetologia 61:1142-1154
King, Wendy C; Hinerman, Amanda S; Belle, Steven H et al. (2018) Comparison of the Performance of Common Measures of Weight Regain After Bariatric Surgery for Association With Clinical Outcomes. JAMA 320:1560-1569
Han, Seung Jin; Fujimoto, Wilfred Y; Kahn, Steven E et al. (2018) Change in visceral adiposity is an independent predictor of future arterial pulse pressure. J Hypertens 36:299-305

Showing the most recent 10 out of 563 publications